News
Urolithin A vs Spermidine: What’s the Difference?
Urolithin A and spermidine are both used in healthy-aging supplement routines, but they're not the same. Urolithin A is more focused on mitochondri...
Best Spermidine Supplements of 2026
The best spermidine supplement isn't the one with the biggest number on the label. It's the one with a clear dose, realistic claims, and a format y...
Spermidine and the Gut Microbiome: How Your Gut Bacteria Produce a Longevity Molecule
Most conversations about spermidine focus on food sources and supplements. Food like wheat germ, aged cheese, or spermidine supplements are the mos...
Why Spermidine Is Called a Caloric Restriction Mimetic
Caloric restriction (eating significantly less without becoming malnourished) is one of the most consistently studied ways to extend lifespan in l...
Spermidine vs. Resveratrol vs. Rapamycin: Comparing Longevity Compounds
Spermidine supports autophagy, which is the body’s built-in cleanup mode. Resveratrol activates pathways linked to longevity genes and mimics some ...
Is Spermidine Safe? Side Effects, Contraindications, and What the Research Actually Says
For most healthy adults, spermidine appears to be safe at the doses used in clinical research and food-based supplementation. The European Food Sa...
How Fasting Increases Your Spermidine Levels (and Why That Matters for Longevity)
Fasting has a reputation problem. Depending on who you ask, it’s either the single most powerful longevity tool available or a dressed-up eating di...
The Mediterranean Diet and Spermidine: Why This Eating Pattern Promotes Longevity
The Mediterranean diet doesn’t need another endorsement. Decades of research have already tied this eating pattern to lower rates of cardiovascular...
Spermidine and Immune Function: Fighting Immunosenescence With Polyamines
Your immune system gets weaker with age. The complex machinery that keeps immune cells functional slowly breaks down with misfired signals, old thr...
Can Spermidine Help With Hair Growth? What Science Says
The short answer: maybe, but the evidence is still early. A handful of studies (including one clinical trial) suggest that spermidine may support ...
Spermidine, Inflammation, and Oxidative Stress: The Anti-Aging Triangle
Aging doesn’t happen all at once. It creeps in through a handful of biological processes that reinforce each other, and three of the most conseque...
Spermidine for Brain Health: Can It Protect Against Cognitive Decline?
The short answer: spermidine looks genuinely promising for brain health, but we’re not at “proven” yet. The longer answer is more interesting and w...