News
Urolithin A vs Spermidine: What’s the Difference?
Urolithin A and spermidine are both used in healthy-aging supplement routines, but they're not the same. Urolithin A is more focused on mitochondri...
Best Spermidine Supplements of 2026
The best spermidine supplement isn't the one with the biggest number on the label. It's the one with a clear dose, realistic claims, and a format y...
Spermidine and the Gut Microbiome: What Gut Bacteria Produce & What Human Studies Show
Your gut microbiome can contribute to the polyamines present in your intestines, including putrescine and spermidine. However, microbial polyamine ...
Spermidine vs. Resveratrol vs. Rapamycin: Evidence, Mechanisms & Safety
There is no evidence-based overall winner between spermidine, resveratrol, and rapamycin. They are biologically and medically different, and none h...
Spermidine and Fasting: Does Fasting Increase Spermidine and Autophagy?
Yes. Human studies show that fasting can increase circulating spermidine, and laboratory research suggests that endogenous spermidine is an importa...
The Mediterranean Diet and Spermidine: Why This Eating Pattern Promotes Longevity
The Mediterranean diet doesn’t need another endorsement. Decades of research have already tied this eating pattern to lower rates of cardiovascular...
Does Spermidine Help Hair Growth? What Human Studies Show
Spermidine may influence the human hair-growth cycle, but the evidence is still preliminary. Laboratory research using isolated human scalp follicl...
Spermidine and Brain Health: What Human Studies Show
Spermidine has become an increasingly studied compound in brain-aging research, but human evidence does not yet show that taking a spermidine suppl...
Spermidine, Putrescine, and Spermine: Understanding the Polyamine Pathway
Every cell in your body produces a small family of molecules called polyamines, low-molecular-weight compounds with two or more amino groups that o...
What Is Spermidine? How It Works & What Human Research Shows
Spermidine is a naturally occurring polyamine found in human cells, plants, animals, microorganisms, and many foods. It belongs to the same family ...
Spermidine and Autophagy: How It Works & What Human Studies Show
Yes - spermidine can promote autophagy in cells and model organisms. Human evidence is now beginning to emerge, but it remains narrow and prelimina...
Spermidine Supplements: Dosage, Types, Safety, and How to Choose the Right One for Healthy Aging
There is currently no universally established therapeutic dose of spermidine for longevity, autophagy, memory, weight loss, or general anti-aging. ...