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Each capsule provides 20 mg of liposomal spermidine 3HCl, and each bottle holds 60 capsules. At one capsule a day, a bottle lasts about 60 days.
Liposomal means the spermidine trihydrochloride is combined with phospholipids from sunflower. That does not show that the capsule is absorbed better or works better than a standard tablet.
The full label serving is in one capsule, so there is nothing to split across the day.
The directions suggest taking the capsule with a meal, at any time of day.
60 capsules last about two months at one capsule a day.
No feeling, symptom or home test confirms that spermidine is having an effect.
Some customers describe changes they notice, others notice nothing in particular. These experiences are not clinical evidence, and there is no proven timeline for autophagy, memory, energy or healthy-aging effects.
This is a dietary supplement. It is not intended to diagnose, treat, cure or prevent any disease.
No human study has compared this product with standard spermidine tablets, or shown that it is absorbed better, increases autophagy, improves memory or extends lifespan.
Food and your own cells already supply some. A supplement adds a fixed daily amount.
In food
24 mg
Wheat germ is one of the richest sources, at about 24 mg per 100 g, followed by soybeans, aged cheese and mushrooms. How much you get depends on what you eat each day.
With age
Your cells make spermidine as well as taking it in from food, and levels in the body tend to decline as people get older.
In your cells
Spermidine takes part in autophagy, the process cells use to break down and recycle worn components. Most of this evidence comes from cell and animal studies; the human research is in Lab & research.
Once a day
20 mg
One capsule with a meal gives 20 mg of spermidine 3HCl in a sunflower phospholipid complex, the same amount whatever you eat. Liposomal Spermidine is designed to support cellular health and healthy aging.*
Food values are representative published measurements (Ali et al., 2011).
The three products differ in labeled amount, how many you take a day and how long a bottle lasts. They have not been compared in a clinical trial, so pick the one that suits you.
$25 a bottle
$0.42 a day · lasts about 60 days
Suits you if you want the lowest-priced format and are happy taking one tablet in the morning and one in the evening.
$40 a bottle
$0.67 a day · lasts about 60 days
Suits you if you prefer one capsule a day in a liposomal format.
A subscription, delivered every 30 days. Pause or cancel any time.
$55 a bottle
$0.46 a day · lasts about 120 days
Suits you if you want a once-daily 50 mg capsule and a bottle that lasts about 120 days.
30-day money-back guarantee
The liposomal amount describes liposomal spermidine, so it does not compare milligram for milligram with the tablets or Pro. No head-to-head study has shown that one format works better.
One active complex at 20 mg, plus three other ingredients and a plant-based capsule shell. Every ingredient is listed under The complete label.
DECLARED ACTIVE
Spermidine 3HCl/phospholipid complex from sunflower
Spermidine trihydrochloride combined with phospholipids from sunflower into one complex, as listed on the Supplement Facts panel. The 20 mg is the weight of the whole complex.
As listed on the Supplement Facts panel.
The shell is hypromellose (HPMC), not gelatin.
The amount of the active complex is stated on the Supplement Facts panel.
Wheat is not listed among the ingredients on the label.
01 · Daily servingThe suggested use is one capsule a day. Taking more has not been shown to add benefit.
02 · With a mealThe directions suggest taking the capsule with a meal. Food has not been shown to change how much spermidine you absorb.
03 · Any mealBreakfast, lunch or dinner all work, since the label names no time of day. One fixed meal makes a missed day less likely.
Settle into the routine and notice how the capsule suits you. No sensation shows that it is working.
There is no proven timeline for autophagy, memory, energy or healthy-aging changes.
About 60 days at one capsule a day.
The active complex contains phospholipids from sunflower. If you react to sunflower, ask a healthcare professional before use.
Not for use by anyone under 18. Do not use if you are pregnant or nursing.
Talk to a healthcare professional first if you take medication or other supplements, have a medical condition, are under medical care or are preparing for surgery.
A lab report tests one finished batch for the items it lists. Published research studies spermidine in other forms, amounts and people. They are different kinds of evidence, so we keep them apart.
None of the studies below tested a liposomal form, and research has not shown that 20 mg is an optimal amount or that spermidine reverses aging or extends life. Spermidine dosage guide
Two kinds of evidence
In a randomized crossover study, oral spermidine raised plasma spermine but not plasma spermidine or putrescine. The authors suggest spermidine is converted before it reaches the bloodstream, so a larger oral amount does not mean proportionally more spermidine in the blood.
Senekowitsch et al., 2023A randomized, double-blind, placebo-controlled study of a high-purity spermidine trihydrochloride found no significant changes in clinical, lipid, chemistry or blood measures, no product-related adverse events, and little change in circulating polyamines. It did not test women, long-term use or this product, and two authors worked for the ingredient’s maker.
Keohane et al., 2024A randomized, placebo-controlled pilot after a third SARS-CoV-2 vaccine dose found the supplement well tolerated, with stronger vaccine responses mainly in people who had responded poorly, and more autophagy-related gene activity in B cells. It was small and specific to this setting.
Alsaleh et al., 2026The SmartAge trial tested a spermidine-rich wheat germ extract in adults with subjective cognitive decline. It did not improve the main memory outcome compared with placebo. The ingredient and amount differ from this product.
Schwarz et al., 2022Reviews marked Verified Buyer come from confirmed purchases.
Reviews describe individual experiences. They are not clinical evidence.
Individual results vary. These are customer experiences, not a clinical study.
That has not been shown for this product. No published test measures its particle size, how much spermidine is encapsulated or how much reaches the blood, and no study has compared it with standard spermidine.
No. The 20 mg on the label is the whole spermidine 3HCl and sunflower phospholipid complex. The label does not state how much of it is spermidine 3HCl.
60 capsules of 20 mg each make 1,200 mg of the complex per bottle. It is not 1,200 mg of spermidine on its own.
Both use spermidine 3HCl. The liposomal capsule combines it with phospholipids from sunflower and is taken once a day; the tablets are taken twice a day and cost less per bottle. No study has shown that either works better. See the tablets
There is no established dose for spermidine supplements. Human studies have used amounts from under 1 mg to 40 mg a day of different forms, and none compared amounts to show that more works better.
Follow the label, and ask a healthcare professional if you have questions about your health or medication. Spermidine dosage guide
Any time, with a meal. Morning and evening have not been shown to make a difference.
About 60 days: 60 capsules at one a day.
There is no proven timeline. Spermidine is not a stimulant, and no sensation shows that it is working.
Spermidine supports autophagy-related activity in cells and animal studies, and a small 2026 human pilot found more autophagy-related gene activity in immune B cells at 6 mg a day. That does not show that this product increases autophagy throughout the body or leads to a particular health outcome.
Yes, for microbiology. The current batch has a certificate of analysis from an ISO/IEC 17025-accredited laboratory covering microbial counts and four pathogens. It does not include a potency, heavy metal or absorption test. It is linked in Lab & research.
The capsule shell is plant-based hypromellose, wheat is not listed among the ingredients, and the active is not a wheat germ extract. If you follow a strict vegan diet, have celiac disease or a severe allergy, ask us for the full documentation before use.
It is not for anyone under 18, and should not be used during pregnancy or nursing. Talk to a healthcare professional before use if you react to sunflower, take medication, have a medical condition, are under medical care or are preparing for surgery.
Start with one bottle, or subscribe and save 20%.
Adds a subscription, delivered every 30 days, 20% off. Pause or cancel any time.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Not for use by persons under 18. Do not use if pregnant or nursing. Consult a healthcare professional before using this or any dietary supplement.
