Best Longevity Supplements

There's more to living a long, healthy life than avoiding illness and injuries. From what I've learned over the past 10 years of testing and refining my own longevity stack, it starts with keeping the body's building blocks strong and supported as you age.

Some supplements are designed to do exactly that by helping your cells function properly, recycling damaged components, and clearing out tired, worn-out cells.

These are called longevity-focused supplements, and they include compounds like NAD+ boosters, fisetin, urolithin A, and spermidine, which all work at a deep cellular level, where aging begins.

But there's another group of supplements that might not directly influence cellular cleanup or mitochondrial renewal, but they still play a big role in how you age. We call these systemic longevity support supplements, and they include things like magnesium, omega-3, and vitamin D. These compounds keep your heart, brain, and immune system running smoothly — all of which are non-negotiable if you want to stay sharp, mobile, and energized in your golden years.

At Neurogan Health, we've been creating and selling longevity supplements for over two years now, but we’ve been in the health space for nearly a decade. In that time, we've been lucky to connect with a growing community passionate about living better for longer. As part of this mission, we've also been writing about the longevity routines of some of today's leading biohackers and researchers. So far, we've covered Bryan Johnson, David Sinclair, Andrew Huberman, Gary Brecka, and Mark Hyman.

And there's more coming.

We hope this overview guide gives you a clearer picture of what longevity supplements are, helping you choose the right ones for your own wellness journey.

Best Longevity Supplements

• Nicotinamide Mononucleotide

• Nicotinamide Riboside

• Fisetin

• CoEnzyme Q10

• Taurine

• Spermidine

• Resveratrol

• Pterostilbene

• Quercetin

• Alpha-ketoglutarate (AKG)

• Berberine

• Apigenin

Nicotinamide Mononucleotide

NMN is a form of vitamin B3 that exists in small quantities in certain foods like broccoli and edamame beans. It's a direct precursor to an important enzyme called NAD (Nicotinamide Adenine Dinucleotide), which is an important coenzyme our cells need to produce energy.

When it comes to longevity, NAD levels serve as an indicator of the aging process. Studies have shown that lower NAD levels are linked to reduced energy levels, slower recovery, and decreased insulin sensitivity [1].

The most common form of NMN supplements are capsules. The body takes NMN and converts it directly into NAD within the cells, helping to increase the body's NAD levels.

Neurogan Health's NMN capsules contain pure, third-party, lab-tested NMN without any fillers or fuss in vegan-friendly capsules, making them easy to integrate into most supplement stacks.

Nicotinamide Riboside

Nicotinamide riboside (NR) is another NAD+ booster. It's also naturally found in foods like milk, and the body converts this compound into NMN before it turns into NAD+.

Yes, it does take a few extra steps, but studies show that it's also efficient at increasing NAD levels [2].

You might find that there are more nicotinamide riboside supplement options out there as well. Not because it's necessarily safer or better than NMN — but because NMN is going through a bit of an identity crisis.

In 2022, a company put forth a request to investigate the potential of NMN as an anti-aging drug through clinical trials. This process stripped NMN's label as a dietary supplement, and many NMN products were taken off the shelves. Since then, there hasn't been much news on whether they're still continuing this pursuit, but a compound can't be both a drug and a supplement. Still, you can find NMN from certain brands, but it's often much easier to source NR supplements.

Fisetin

Fisetin is a plant flavonoid most commonly associated with strawberries. In its pure form, fisetin is a bright yellow powder, and it's used as a dietary supplement for its high antioxidant content and its potential as a senolytic compound.

Senolytics help the body tag and clear out senescent (damaged, non-dividing) cells that build up with age.

Our pure fisetin capsules are made from Rhus succedanea extract (Japanese wax tree), a rich natural source of fisetin and highly refined for purity. We make our supplements in-house at our San Diego GMP-certified facility to offer the most competitive price points for our products.

CoEnzyme Q10

CoEnzyme Q10, or CoQ10, is a common dietary supplement for supporting cardiovascular health. It's a naturally made compound in the body, but you can also get it in your diet from meat, fish, and nuts.

The body uses coQ10 to help generate energy in the mitochondria. It also acts as an antioxidant, protecting cells from oxidative damage from stress or environmental factors.

CoQ10 comes in capsules that you can easily find at your local pharmacy or health food store. Our Neurogan Health CoQ10 contains pure coQ10 with added black pepper powder to help with efficient absorption.

Taurine

Taurine is an amino acid found in meat and foods, and it's a common ingredient in energy drinks and sports supplement formulas. What's interesting about taurine is that it's not a typical amino acid because it's not used as a building block for proteins. Instead, taurine floats freely in tissues and has its own set of jobs to perform, especially in the brain, heart, retinas, and muscles.

Taurine helps support cell hydration and mineral balance, mitochondrial function, calcium signaling, and muscle recovery, and it's what's known as "conditionally essential." This means our bodies can produce taurine, but not enough when we’re stressed (even working out a lot can put stress on the body), sick, or aging. Recent studies link taurine levels to healthy aging in animals [3].

The Neurogan Health taurine capsules provide 1200 mg of pure vegan-based taurine, allowing you to get high, consistent doses that suit a variety of diets.

Spermidine

Spermidine is a naturally occurring polyamine — a technical term for a small molecule made up of carbon, nitrogen, and hydrogen — it's important for healthy aging because it's involved in cell growth and maintenance.

You can get trace amounts of spermidine through your diet if you consume a lot of aged cheeses, soybeans, wheat germ, and mushrooms, but to get the real benefits for cellular health, you'll want a high-quality supplement.

Spermidine is best known for supporting autophagy. This is the body's recycling process of damaged cell parts, which often slows down as we age.

At Neurogan Health, spermidine is one of our top-selling healthy aging supplements. It’s available in tablet, liposomal capsule, and liquid form — but up to 100 times more concentrated and pure than wheat germ extract.

Resveratrol

Resveratrol is one of the most recognized compounds in the longevity space. It first caught widespread attention with the "French Paradox." Researchers were trying to understand why people in France have relatively low rates of heart disease despite a diet high in fats. One reason that might explain this is that resveratrol is found in red wine, and France is a renowned wine-producing country [4].

Resveratrol is a polyphenol found in grapes and other berries that has several key healthy aging pathways, particularly regarding cellular stress resistance, healthy inflammatory control, and gene activation [5].

Neurogan Resveratrol is sourced from Japanese knotweed, which is known for its high potency and bioavailability. We have pure resveratrol capsules, or if you’re looking for a blend,  we formulate resveratrol alongside NAD+ boosters like NAD+ and NMN for a powerful, ready-made, healthy aging stack.

Pterostilbene

Pterostilbene comes from the same family as resveratrol and is an antioxidant in plants, but it has been called the "better-absorbed cousin" of resveratrol.

What makes pterostilbene unique is its chemical composition. It has two methoxyl groups instead of hydroxyl groups — a small change with significant differences in how the body handles it. Several studies show that pterostilbene is much more stable and better absorbed in the gut, allowing the compound to reach your cells and tissues for its cellular health benefits [6].

Both resveratrol and pterostilbene have similar longevity pathways through the activation of sirtuins (SIRt1) that support healthy aging at the cellular level and strong antioxidant support, helping to manage inflammation and DNA damage [6].

One of our favorite pterostilbene supplements comes from Thorne in its Memoractiv™ blend. It contains pterostilbene and other cognitive function supplements like ginkgo, bacopa, and lutein, making it more targeted for memory, productivity, and creativity. One thing to note is that this formula contains 50 mg of caffeine, which could be a bonus for some but might not suit those sensitive to caffeine.

Quercetin

Quercetin is another plant flavonoid found in apples and green tea. It's a unique compound in the longevity supplement space because it acts like a multi-tool: it supports senolytic activity and has antioxidant and immune-modulating properties.

Quercetin isn't as powerful as a senolytic compound as fisetin, but they're often combined in formulations for their synergetic effects [7]. What makes this compound appealing for some is that it also has strong anti-inflammatory potential through the NF-κB pathway, which may contribute to healthy inflammation levels to help with allergies and some of the hallmarks of the aging process [8].

Pure Encapsulations offers an excellent, affordable quercetin supplement made with no fillers and easy to integrate alongside other supplement stacks.

Alpha-ketoglutarate (AKG)

AKG is a compound naturally occurring in the body and is involved in the Krebs cycle (energy production from the foods we eat) and amino acid metabolism. Although the body naturally produces AKG, it declines with age.

Not only does AKG help with energy production, but it's been shown to modulate systemic inflammation and muscle protein synthesis, which are staples in anti-aging protocols, especially for active adults [9].

Doublewoods has an AKG supplement for a good value with top-rated reviews.

Berberine

Berberine is a plant-based alkaloid most commonly taken as a dietary supplement for blood sugar and metabolic health. More recently, it's gained a lot more attention in the longevity space because research has found that berberine may mimic some of the effects of calorie restriction and exercise at a cellular level — both proven to extend the lifespan of many organisms [10].

Berberine isn't known for cleaning out old cells (senolytic) like fisetin or boosting mitochondrial function like NMN, but it does help the body stay balanced by keeping blood sugar and inflammation in check, which is really important for a healthy aging process.

Neurogan Health Berberine is naturally sourced and refined for purity for a clean-label formula with no artificial colors or fillers.

Essential Vitamins and Minerals for Longevity

Compounds like NMN and fisetin work at the cellular level, but vitamins and minerals also contribute to keeping your entire body running smoothly. Without these components, even the best longevity stacks can fall flat.

Here's a compilation of systemic longevity support nutrients — we've categorized them separately because they may not directly contribute to autophagy or mitochondrial renewal, but they're still just as important for keeping vital systems in check as you get older.

Best Longevity Blends

Longevity blend supplements are great for people who want a simple way to get all these cellular health compounds without buying several separate supplements. The upside is that they're convenient and often formulated by experts to work well together. But one downside is that you can't always control the exact dose of each ingredient, and sometimes you're paying for stuff you don't need.

Overall, they're a good place to start for people who want a balanced, all-in-one option without having to build a stack from scratch. Some of our favorite longevity blends include:

• Neurogan Health: NAD+ Resveratrol

• Thorne: ResveraCel

• Pure Encapsulations: Longevity Nutrients

• ProHealth Longevity: Uthever NMN + Resveratrol + TMG

Neurogan Health NAD+ Resveratrol

Price: $35.00 for 30 servings

Where to Buy: Neurogan Health

Origin: San Diego, California

How to Take: 1 capsule daily in the morning

Best For: People who want simple, direct support for energy and healthy aging

Who Should Avoid: Those on NAD+ precursors looking for a different approach

Key Features:

• Liposomal NAD+ for better absorption — ready to use by cells

• Trans-resveratrol for antioxidant support (a more bioavailable form of resveratrol)

• Easy to take in capsule form

• No fillers, no artificial colors, vegan-friendly capsules

Ingredients (per serving)

• Liposomal NAD+: 125 mg

• Trans-resveratrol: 250 mg

This NAD + Resveratrol capsule formula combines two well-known longevity support compounds that work through complementary pathways. Liposomal NAD+ delivers the active coenzyme directly, skipping the conversion step required by NMN or NR. Trans-resveratrol helps with the activations of sirtuins and provides oxidative stress defense.

Pros:

• The liposomal delivery system improves the absorption

• No need to convert it into NAD+

• Trans-resveratrol has better bioavailability

• Affordable and clean-label

Cons:

• Doesn't include methylation support like TMG

• It may need to be stacked with other compounds for broader longevity support

Thorne ResveraCel

Price: $60.00 for 30 servings

Where to Buy:  Thorne

Origin: USA

How to Take: 2 capsules daily in the morning

Best For: People who want a comprehensive NAD+ boosting formula

Who Should Avoid: Those looking for pure NAD+ (this is a precursor-based blend)

Key Features:

• NR to boost NAD+ levels

• Contains resveratrol and quercetin for cell protection

• Contains TMG for methylation support

• High-quality, research-backed ingredients

Ingredients (per serving)

• Nicotinamide Riboside (as Niagen): 415 mg

• Resveratrol: 150 mg

• Quercetin Phytosome: 250 mg

• Trimethylglycine (TMG): 500 mg

ResveraCel is Thorne's all-in-one longevity blend to support NAD+ production, cellular metabolism, and healthy aging. It contains nicotinamide riboside, resveratrol, quercetin, and trimethylglycine to support methylation and homocysteine balance.

This balanced stack helps with the body's natural processes for how the body handles stress, produces energy, and regulates mood.

Pros:

• Multipathway approach to healthy aging

• Includes methylation and antioxidant support

• Niagen NR is clinically studied

Cons:

• Pricier than single-ingredient options

• It may not be ideal for those sensitive to quercetin or polyphenols

Pure Encapsulations Longevity Nutrients

Price: $66.20 for 30 servings

Where to Buy: Pure Encapsulations

Origin: USA

How to Take: 8 capsules daily with meals (split doses recommended)

Best For: People looking for a premium multivitamin targetted for healthy aging

Who Should Avoid: Those who prefer taking fewer pills or want a more minimalist stack

Key Features:

• Comprehensive multivitamin + antioxidant support

• Includes CoQ10, lutein, lycopene, and alpha-lipoic acid

• Highly bioavailable nutrient forms

Ingredients (per serving)

• CoQ10: 60 mg

• ALA: 200 mg

• Lutein: 6 mg

• Lycopene: 6 mg

• Full-spectrum vitamins+minerals

The Longevity Nutrients is a multivitamin containing essential vitamins and minerals and targeted healthy aging ingredients like CoQ10, lutein, lycopene, and alpha-lipoic acid for cellular protection and heart health.

Unlike standard multivitamins, this blend is made with bioavailable nutrients, making it easier for the body to absorb and use for systems involved in aging, like the brain, eyes, cardiovascular system, and metabolism.

Pros:

• Broad daily support for aging adults

• Bioavailable forms for better absorption

• Includes antioxidants and mitochondrial support compounds

Cons:

• Requires eight capsules daily

• Doesn't include NAD+ support or senolytics

ProHealth Longevity Unthever NMN + Resveratrol, TMG

Price: $74.99 for 30 servings

Where to Buy: ProHealth

Origin: USA

How to Take: Take one scoop of the powder daily, preferably with a meal high in fat

Best For: People who want to target NAD+ support and prefer not to take pills

Who Should Avoid: Those looking for a more comprehensive antioxidant blend

Key Features:

• Features Uthever NMN, a clinically validated NMN source

• Powder formula to mix into water

• Stacks Trans-resveratrol and TMG for sirtuin and methylation support

Ingredients (per serving)

• Uthever® NMN: 250 mg

• Trans-resveratrol: 250 mg

• TMG: 200 mg

This longevity blend uses a registered brand of NMN by Unthever, which is a clinically tested compound. It's also combined with trans-resveratrol and trimethylglycine, which all work together for cellular energy production, protection, and healthy gene expression.

Adding THM helps to maintain methylation, a process the body uses for detox, brain function, and balancing homocysteine — a marker linked to heart and brain health.

Pros:

• Uthever NMN is purity-tested, and clinically studies

• Includes trans-resveratrol and methylation support

Cons:

• Powdered formula is not as easy to take on the go

• Lacks senolytics or mitochondrial boosters like CoQ10 or AKG

Finding The Right Longevity Supplement For Your Routine

In this guide, we've reviewed many of the top longevity compounds and blends that target aging from different angles, including NAD+ production, antioxidant defense, methylation, and inflammation balance. We considered things like:

• Ingredient quality and transparency

• Mechanism of action

• Ease of use

• Brand reputation

• Price-to-value ratio

Each product offers something unique for those looking to feel their best as they age, combined with a healthy lifestyle that includes a balanced diet, exercise, and reduced stress. The best pick comes down to your personal health priorities like energy, clarity, recovery, or long-term wellness, but any of these options are excellent places to start.

Resources:

1. Schultz, M. B., & Sinclair, D. A. (2016). Why NAD+ declines during aging: it’s destroyed. Cell metabolism, 23(6), 965-966.

2. Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell metabolism, 27(3), 529-547.

3. Santulli, G., Kansakar, U., Varzideh, F., Mone, P., Jankauskas, S. S., & Lombardi, A. (2023). Functional role of taurine in aging and cardiovascular health: an updated overview. Nutrients, 15(19), 4236.

4. Catalgol, B., Batirel, S., Taga, Y., & Ozer, N. K. (2012). Resveratrol: French paradox revisited. Frontiers in pharmacology, 3, 141.

5. de Sá Coutinho, D., Pacheco, M. T., Frozza, R. L., & Bernardi, A. (2018). Anti-inflammatory effects of resveratrol: Mechanistic insights. International journal of molecular sciences, 19(6), 1812.

6. Nagarajan, S., Mohandas, S., Ganesan, K., Xu, B., & Ramkumar, K. M. (2022). New insights into dietary pterostilbene: sources, metabolism, and health promotion effects. Molecules, 27(19), 6316.

7. Lee, E., Carreras-Gallo, N., Lopez, L., Turner, L., Lin, A., Mendez, T. L., ... & Dwaraka, V. B. (2024). Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions. Aging (Albany NY), 16(4), 3088.

8. Ebrahimpour, S., Esmaeili, A., Dehghanian, F., & Beheshti, S. (2020). Effects of quercetin-conjugated with superparamagnetic iron oxide nanoparticles on learning and memory improvement through targeting microRNAs/NF-κB pathway. Scientific reports, 10(1), 15070.

9. Xu, M., Zhang, Q., Liu, X., Lu, L., & Li, Z. (2024). Impact of Alpha-Ketoglutarate on Skeletal Muscle Health and Exercise Performance: A Narrative Review. Nutrients, 16(22), 3968.

10. Feng, X., Sureda, A., Jafari, S., Memariani, Z., Tewari, D., Annunziata, G., ... & Shen, A. Z. (2019). Berberine in cardiovascular and metabolic diseases: from mechanisms to therapeutics. Theranostics, 9(7), 1923.