If you used to pick up your nicotinamide mononucleotide (NMN) supplements from your local specialty vitamin shop, you may have noticed that in 2022, they seemed to disappear off the shelves.
The main reason was a regulatory technicality: NMN was being investigated as a potential drug, which effectively removed its status as a dietary supplement — a compound can’t be both a drug and marketed as a dietary supplement.
NMN supplements became so popular because of the research supporting their ability to support NAD+ levels. This is especially exciting in the field of longevity sciences, where researchers investigate ways to slow the natural aging process.
The good news as of September 2025, is that the FDA reinstated NMN supplements online like ours as a lawful dietary supplement.
Timeline of NMN Supplements on The Market
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Early 2010s: NMN gained popularity in the scientific community due to its potential to support NAD+ levels and longevity.
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2019: NMN hits the market as a dietary supplement, widely available online and in specialty supplement stores.
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2021: Research on animals and in vivo shows NMN’s benefits for NAD+ levels, sparking interest from pharmaceutical drug companies.
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November 2022: The FDA begins investigating NMN's status as a new dietary ingredient (NDI) due to its growing use and the potential for drug classification.
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Early 2023: NMN is removed from the market as the FDA considers it for drug classification, largely due to its promising anti-aging research.
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Mid-2023: The Natural Products Association (NPA) and the Alliance for Natural Health USA asked the FDA to keep NMN classified as a dietary supplement and stop enforcing its sale ban. However, the FDA didn't decide within 180 days.
So, what happened?
The FDA's decision (or lack thereof) had a major impact on the NMN market, causing it to be banned from platforms like Amazon.
The Alliance for Natural Health USA was disappointed, claiming that the FDA is siding with drug companies instead of supporting businesses that make affordable health supplements. There's some news suggesting that a lawsuit might be needed to challenge the FDA's decision on recategorizing NMN as a dietary supplement again. -
September 2025: FDA reinstates NMN as a dietary supplement ingredient.
Why Did the FDA Ban NMN?
The real turning point for NMN came when pharmaceutical companies began to explore the potential of NMN as a therapeutic agent.
The research surrounding NMN and its effects on NAD+ levels caught the attention of these companies, leading to the possibility of NMN being classified as a drug. This potential reclassification would mean that its sale as a supplement could conflict with future drug patents, and this played into the FDA's decision to remove NMN from the shelves.
Has the FDA Ever Approved NMN?
No, the FDA has never approved NMN as a drug despite some claims circulating online. The confusion about NMN's FDA approval may stem from ongoing research and interest in its potential as a drug, but as of now, NMN remains unapproved for any specific health claims.
Does Amazon Sell NMN?
Since the unofficial ban in late 2022 and into 2023, NMN, for the most part, disappeared from mainstream retailers like Amazon.
However, NAD+ supplements serve a similar function but are still available. These supplements are often marketed as alternatives to NMN. A viral example of this is nicotinamide riboside (NR), which is another precursor to NAD+.
As of right now, we still don’t see any pure NMN products sold on Amazon, but the shift in the FDA’s categorization of NMN may convince Amazon to follow suit. We’re not exactly sure when you’ll be able to purchase NMN products on Amazon.
Is NMN Illegal?
NMN is currently legal in the United States. As of September 29, 2025, the FDA formally declared nicotinamide mononucleotide a dietary supplement, resolving the issue of its previously grey area status as a research drug.
NMN Updated News
Neurogan Health still offers NMN supplements in various formats such as NMN capsules, NMN tablets, and tincture drops.
Our NMN products are carefully formulated to stay within safe dosage limits. We recommend taking around 450mg of NMN a day. This ensures you receive a product that supports your wellness goals without compromising quality or safety.
We know the NMN supplements situation can be confusing, but we’re here to help you stay informed. You never know what might change with the laws of NMN, so we'll keep you in the loop with any updates about NMN and its availability on Amazon.
