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GHK-Cu Neck & Face Serum amber dropper bottle on pink marble beside a pool of serum

A lightweight copper peptide serum for face and neck

GHK-Cu Copper Peptide Neck & Face Serum is a leave-on skincare formula built around 4% GHK-Cu, also known in cosmetic use as Copper Tripeptide-1.

Each 30 mL bottle is formulated to a strength of 1,200 mg GHK-Cu.

The formula combines GHK-Cu with aloe vera juice, glycerin, kojic acid, niacinamide and lightweight plant oils. The result is a thin serum designed to sit comfortably under moisturizer, sunscreen or makeup.

Read the full GHK-Cu benefits and research review

What you can expect with consistent use With consistent use

  • Supports smoother-looking skin
  • Helps skin feel softer and more conditioned
  • Supports a more even-looking complexion
  • May help fine surface lines look softer over time
  • Adds lightweight hydration without a rich cream texture
  • Fits into morning or evening skincare
Full descriptionThe formula · Reading the label · Who it suits · Limitations

A leave-on GHK-Cu face and neck serum with niacinamide, kojic acid, aloe and conditioning plant oils in a lightweight dropper formula.

The formula

  • 4% GHK-Cu, 1,200 mg per 30 mL bottle
  • A tone-supporting formula. Niacinamide (vitamin B3) and kojic acid are included alongside the copper peptide rather than sold as separate steps.
  • A lightweight base. Aloe vera juice and glycerin form the foundation of the serum, with papaya seed, jojoba and rice bran oils and vitamin E added for conditioning.
  • Lemon peel oil and lemon essential oil
  • A paraben-free preservative (phenoxyethanol with ethylhexylglycerin)
  • An amber glass dropper that helps protect the formula from light and dispenses a few drops at a time

Reading the label

1,200 mg is the amount per bottle, not per drop. In 30 mL that is 40 mg per mL, the 4% concentration.

Copper Tripeptide-1 is the ingredient-list name for GHK-Cu, the copper-bound form of the tripeptide Gly-His-Lys.

Not the Advanced serum. The Advanced GHK-Cu Face & Neck Serum has the same labeled strength, 4% and 1,200 mg, in a bottle with a lockable pump.

Who it suits

Adults with normal, dry, combination or uneven-looking skin who want a daily copper peptide serum for the face and neck that layers under moisturizer and SPF. It is a face and neck serum, not an eye product.

Limitations

This is a cosmetic serum for skin appearance and conditioning, not a treatment for any skin condition.

GHK-Cu has been studied for decades in skin and tissue biology, including research on extracellular-matrix remodeling, collagen-related pathways and visible signs of aging. Published clinical evidence for topical GHK-Cu remains limited, and studies of other creams or research formulations are not proof that this finished serum will produce the same results. A 2025 review noted that, despite wide cosmetic use, published information on GHK-Cu skin permeability and clinical effectiveness remains limited.

Controlled studies of 5% niacinamide have reported improvements in fine lines, texture, red blotchiness and hyperpigmented spots over 12 weeks. This serum does not state a 5% niacinamide concentration, so those results do not transfer directly.

Kojic acid is widely studied in pigmentation-related skincare, but its effects depend on concentration and formulation. This serum is not a treatment for melasma or another pigment disorder.

The 8 to 12 week timeline on this page is a practical way to judge the serum, not a timeline established in clinical studies of this finished formula. Results vary.

The formula contains lemon peel oil and lemon essential oil, so it is not fragrance-free and may not suit very reactive skin.

GHK-Cu Neck & Face Serum amber dropper bottle on a dark marble counter

Copper Tripeptide-1

What GHK-Cu is

What the active is, and why it comes in amber glass.

  1. 01

    GHK-Cu is the copper-bound form of the tripeptide Gly-His-Lys, three amino acids (glycine, histidine and lysine) holding a copper ion.

  2. 02

    It has a long research history in skin biology and tissue remodeling, which is why Copper Tripeptide-1 is now used in many cosmetic formulas.

  3. 03

    In this serum it sits in a light aloe base. Amber glass helps protect the formula from light, and the dropper dispenses a few drops at a time.

Read the lab results

What goes into the bottle

The label lists 14 ingredients. These cards cover the ones that shape how the serum feels and what it is there to do.

COPPER PEPTIDE ACTIVE

GHK-Cu

Copper Tripeptide-1

The primary active. It has a long research history in skin and tissue biology and is used here for the look and feel of the face and neck.

Role in the formula Primary copper peptide active
In this bottle 1,200 mg · 4%
On the label No. 5
The complete label listAll ingredients · in label order
  1. Aloe Barbadensis (Aloe Vera) Juice
  2. Guar Hydroxypropyltrimonium Chloride (Guar Gum)
  3. Vegetable Glycerin
  4. Kojic Acid
  5. GHK-Cu (Copper Peptide)
  6. Carica Papaya (Papaya Seed) Oil
  7. Simmondsia Chinensis (Jojoba) Seed Oil
  8. Ethylhexylglycerin
  9. Phenoxyethanol
  10. Tocopherol (Vitamin E) Oil
  11. Niacinamide (Vitamin B3)
  12. Oryza Sativa (Rice Bran) Oil
  13. Citrus Medica Limonum (Lemon) Peel Oil
  14. Lemon Essential Oil

In label order, with standard ingredient names.

Color from the copper peptide

GHK-Cu itself gives the serum its tint, with no added dye.

Lemon oils on the label

It contains lemon peel oil and lemon essential oil, so it is not fragrance-free.

Paraben-free preservative

Phenoxyethanol with ethylhexylglycerin keeps the water-based serum stable after opening.

What to expect over 12 weeks

Look for gradual changes in how skin feels and looks, not dramatic day-to-day shifts. Words from customers who reviewed this serum mark the way.

  1. First days

    Notice how it feels

    The first change you notice may be how your skin feels after the aloe, glycerin and plant oils. Take a starting photo of your face and neck in daylight so you have something to compare with later.

    “The consistency and feel of this product with great ingredients is amazing.” Joanne C.

  2. Weeks 1 to 4

    Find your routine

    Pay attention to hydration, softness and whether the serum suits your routine. If your skin is reactive, start more slowly, every other day.

    “This serum helped my Skin feel smooth and soft.” Mendy L.

  3. Weeks 5 to 8

    Look at texture and tone

    With consistent use, changes in skin appearance may become easier to judge. Look at texture and overall tone rather than checking individual wrinkles every day.

    “My skin is brighter and smoother, very hydrating product.” Heidi W.

  4. Weeks 9 to 12

    Compare with your start

    This is a more useful point to compare your skin with where you started. Take new photos in similar lighting for an objective comparison. One bottle lasts about 60 days with once-daily use, so 12 weeks takes about two bottles.

    “I’m finishing up my second vial and can truly tell a difference.” John B.

Quotes are from verified customer reviews of this serum and describe individual experiences, not a clinical study. Results vary. This is a cosmetic product.

A few drops in a simple routine

Start once a day. If your skin tolerates it well, you can use it morning and evening.

Hands cupping water over a washbasin01 · Cleanse

Start with clean, dry skin

Wash your face and neck with a gentle cleanser and pat dry. If you use toner, apply it first.

Drops of serum from the dropper onto a fingertip02 · A few drops

Pat a thin layer on face and neck

Dispense a few drops onto clean fingertips and pat them across your face and neck. More product is not better. Let the serum absorb before heavier products.

The serum next to a GHK-Cu face cream jar03 · Finish

SPF by day, moisturizer at night

Morning: follow with moisturizer if needed and a broad-spectrum sunscreen. Evening: follow with your usual moisturizer or our GHK-Cu face cream.

If it pills or shows blue

Too much serum can roll up under makeup or sunscreen and leave a faint blue film. Use fewer drops, pat rather than rub, and let it dry fully before the next layer.

Patch test first

Especially worthwhile if your skin is reactive. Start every other day, avoid broken or inflamed skin and the eye area, and stop if irritation persists.

With retinoids, acids or strong vitamin C

The practical concern is tolerability. This serum already contains kojic acid, niacinamide and essential oils, so use retinoids, exfoliating acids or prescription treatments in a separate routine, or introduce them gradually.

Complete your routine

Fits alongside a gentle cleanser, hyaluronic acid, moisturizer, sunscreen and other simple hydrating products. Apply lighter layers first.

What the testing shows, and what published research can tell us

The certificate checks one production lot of this serum. The research cards explain why its ingredients are used. See the Neurogan evidence map.

Two kinds of evidence

Lab reportTests a specific production lot of this finished serum.
Published researchStudies GHK-Cu or supporting ingredients in other formulations.
[1]
PilotLimited human evidence

GHK-Cu and skin appearance

Older reviews summarize small human topical studies reporting changes in visible signs of aging, firmness and elasticity. Modern reviews describe the clinical evidence as limited and formulation-specific.

Read the full GHK-Cu review

Neurogan evidence map · GHK-Cu
[4]
50Women · 12 weeks

Niacinamide and aging skin

A randomized split-face study tested a 5% niacinamide moisturizer in 50 women for 12 weeks and reported improvements in fine lines, texture, red blotchiness and hyperpigmented spots compared with control.

Bissett et al., Int J Cosmet Sci, 2004
[5]
ReviewPigment research

Kojic acid

Kojic acid has a long history in research on hyperpigmentation and melasma. A 2020 review covers its background, suggested mechanism and the studies evaluating it in melasma.

Zachary et al., Skinmed, 2020
References · Ingredient research in other formulations, not studies of this serum 5
  1. Neurogan Science. GHK-Cu: evidence review (V2). Research maturity: pilot. Evidence strength: limited. Read the review ↗
  2. Mortazavi SM, et al. Topically applied GHK as an anti-wrinkle peptide: advantages, problems and prospective. Bioimpacts. 2025. PMC11830136. Read the paper ↗
  3. Pickart L. The human tri-peptide GHK and tissue remodeling. J Biomater Sci Polym Ed. 2008. PMID 18644225. Read on PubMed ↗
  4. Bissett DL, et al. Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. Int J Cosmet Sci. 2004. PMID 18492135. Read on PubMed ↗
  5. Zachary CM, et al. Kojic acid for melasma: popular ingredient in skincare products. Skinmed. 2020. PMID 33160435. Read on PubMed ↗

Two serums and a cream, side by side

They differ in formula, texture, bottle and price per day. No study has compared these finished products, so choose the format that fits your routine.

This page

GHK-Cu Neck & Face Serum

Everyday face and neck serum

$45 a bottle

$0.75 a day · lasts about 60 days

GHK-Cu
1,200 mg
Texture
Lightweight serum
Package
1 oz amber dropper

Suits you if you want a lightweight dropper serum with GHK-Cu, niacinamide and kojic acid at the lower price.

A subscription, delivered every 30 days. Pause or cancel any time.

Advanced GHK-Cu Face & Neck Serum

Pump-format Advanced serum

$51 a bottle

$1.70 a day · lasts about 30 days

GHK-Cu
1,200 mg
Texture
Lightweight serum
Package
1 oz lockable pump

Suits you if you prefer the same strength in a lockable pump.

Advanced GHK-Cu Face Cream

Moisturizer with GHK-Cu

$50 a bottle

$0.83 a day · lasts about 60 days

GHK-Cu
2,400 mg
Texture
Rich cream
Package
2 oz jar

Suits you if you want a richer moisturizer with higher GHK-Cu content.

30-day money-back guarantee

Days per bottle or jar assume daily use and depend on how much you apply.

What customers are saying

Reviews marked Verified Buyer are from confirmed purchases. They describe personal experience with this finished serum and are not clinical evidence.

4.2
Rated 4.2 out of 5 stars
Based on 51 reviews
Customers Talked About
Keywords
Keywords
Rating
Ratings
51 reviews
  • S
    Sylvia
    Rated 2 out of 5 stars
    10/25/26
    2 Stars

    I've gotten this before and it worked great. most recently when I reordered, it didn't have that characteristic blue tint, so it seems a bit sus and I wonder if it was mis-made or if they changed the formula. if there's no blue, it probably doesn't actually have copper in it anymore

  • SF
    Sharon F.
    Verified Buyer
    Rated 5 out of 5 stars
    10/20/26
    I put this serum on my face morning and evening and can actually FEEL it working.

    I've gotten so many compliments on my skin since I started using it. I'm now on my 3rd bottle!!

  • D
    David
    Rated 5 out of 5 stars
    10/14/26
    5 Stars

    Arrived fast in a timely manner after changing the Drop Off date

  • AD
    Allie D.
    Verified Buyer
    Rated 1 out of 5 stars
    8/12/26
    terrible

    I broke out in a full face of pustules - whiteheads, like cystic all over my face from this. I asked to send back and get a refund and no one ever responded.

  • A
    Aleita
    Rated 1 out of 5 stars
    7/11/26
    1 Star

    It definitely does not go under makeup. It leaves clumps. I did not like this at all.

  • JG
    Jason G.
    Verified Buyer
    Rated 2 out of 5 stars
    6/26/26
    Great!

    Good stuff!

  • S
    sergio
    Rated 1 out of 5 stars
    6/24/26
    1 Star

    2 out of the 3 I ordered where a white color serum. Which indicates no copper being mixed in properly trying to reach this company through email still waiting on a response four days later.

  • J
    John
    Rated 5 out of 5 stars
    6/23/26
    5 Stars

    Really high quality serum. Seeing results in skin tone and brightness already. Love it so far!

  • F
    Fusi
    Rated 1 out of 5 stars
    6/22/26
    1 Star

    Didnt make a difference for me and I used it religiously for 30 days.

Individual results vary. These are customer experiences, not a clinical study.

Questions we hear most often

It is designed to support smoother-looking, softer and more even-looking skin while adding lightweight conditioning. Ingredient research exists for GHK-Cu, niacinamide and kojic acid, but this finished serum has not been clinically tested to reproduce every effect reported in those studies. See the research.

Give it 8 to 12 weeks of daily use. Skin feel may change earlier, while visible changes in texture or fine lines are better judged over several weeks. That is a practical benchmark, not a guaranteed result window.

Compare your skin over weeks, not day to day. Look at texture, softness, hydration, tone and overall conditioned appearance. Photos taken in similar lighting are more useful than memory.

Yes. Apply a few drops to clean, dry skin and let the serum absorb before moisturizer or sunscreen. Avoid direct contact with the eyes.

Yes. Start once daily. If your skin tolerates the formula well, you can use it morning and evening. Using it more often is not automatically better.

Neither time has been shown to be better. Morning use works under moisturizer and SPF; evening use works under your night moisturizer. Consistency matters more than the time of day.

Yes. It is a leave-on facial serum, so you do not need to rinse it off before bed.

About 60 days of once-daily use, depending on how many drops you use. Subscribe and Save takes 20% off every bottle.

Both hold 1,200 mg of GHK-Cu at 4% in 1 oz. The Advanced serum comes in a lockable pump bottle and costs more. This one comes in an amber glass dropper bottle. Compare them.

No. No cosmetic serum removes wrinkles. Used daily alongside sunscreen, it may help fine lines look softer over time.

Possible topical reactions include irritation, redness, dryness, stinging, itching or breakouts. The formula also contains kojic acid and lemon-derived oils, so a reaction is not necessarily caused by the copper peptide. Stop if irritation persists.

Anyone sensitive to one of its ingredients. People with very reactive skin or sensitivity to essential oils may prefer a simpler fragrance-free formula. Do not apply it to broken or significantly inflamed skin.

No. It contains lemon peel oil and lemon essential oil, and customers often mention its pleasant scent. There are no parabens.

It is not an eye serum. Avoid the eyelids and the area right around the eyes, because the formula contains kojic acid, lemon peel oil and lemon essential oil. For the eye area, choose a product made and labeled for it.

There is no universal never-combine list. The practical issue is cumulative irritation, so introduce retinoids, exfoliating acids, strong vitamin C or prescription skin treatments separately, or use them at a different time of day. How to use copper peptides

Yes, if your skin tolerates them. Apply lighter formulas first and let each layer settle before the next. If pilling or irritation occurs, simplify the routine.

Use fewer drops, pat rather than rub, and let it dry completely before makeup or sunscreen. Some customers have reported pilling when they used too much.

A light tint is normal. Copper-peptide complexes have a characteristic blue color, and the GHK-Cu contributes to the color of the serum. If your serum looks cloudy or has separated, contact us with the lot number on the bottle.

Yes. It is made for the face and neck, and the same thin layer works on the upper chest. Patch test a new area first.

Microneedling breaks the skin barrier, so follow your professional's advice or the device instructions. Many people wait until the skin has settled before applying any serum.

Yes. A Qalitex certificate for lot DK25-CPG2-3 documents GHK-Cu potency, heavy metals and microbiological testing. See the lab results.

We offer a 30-day money-back guarantee. If you are not happy for any reason, contact us and we will give you a full refund.

Still have a question? Talk to us

Build GHK-Cu into your daily routine

A concentrated 4% GHK-Cu serum with 1,200 mg per 30 mL bottle, combined with niacinamide, kojic acid, aloe and conditioning plant oils.

  • Use a few drops daily and build up as your skin tolerates it
  • About 60 days per bottle with once-daily use, depending on how many drops you use
  • 20% off every bottle with Subscribe and Save, pause or cancel any time
  • Try it for 30 days, risk-free

Explore all GHK-Cu products

GHK-Cu Copper Peptide Neck & Face Serum in a dropper bottle for skin barrier health.
GHK-Cu Copper Peptide Neck & Face Serum4% GHK-Cu · 1,200 mg · 30 mL
$45$36

Adds a subscription, delivered every 30 days (about one bottle per delivery).

Ships in 1 to 3 business days

For external use only. Avoid contact with the eyes. Patch test before use and stop if irritation persists. Keep out of reach of children. This cosmetic product is not intended to diagnose, treat, cure or prevent any disease.