In the world of longevity supplements, spermidine is a lesser-known but incredibly intriguing compound that's quietly present in many everyday foods like soybeans, mushrooms, and whole grains.
What's exciting is the emerging research pointing to spermidine's potential to support our health, especially as we age. Experts are beginning to piece together that spermidine isn't just a dietary component. It's shaping to be a key player in supporting mitochondrial function, which may help reduce the risk of age-related diseases, including heart disease and possibly dementia.
This isn't the only area of interest, though.
Early studies also explore how spermidine might relate to cognitive functions and overall liver health, adding to its intriguing profile. While the potential health benefits of spermidine are exciting, it's important to remember that these findings are part of an evolving field of study.
This article aims to deliver an informative overview of spermidine and how this intriguing compound might play a role in a well-rounded approach to health and wellness. Still, it should not replace the advice of a healthcare professional, and we are by no means implying that Neurogan Health supplements can prevent, cure, or mitigate any illnesses.
With that out of the way, let's get into the potential benefits of spermidine supplements.
What is Spermidine?
At a molecular level, spermidine is a natural polyamine — a class of organic compounds with more than two amino groups. Polyamines play an important role in cellular functions, from cellular growth and renewal to overall maintenance through DNA stability and gene expression.
Spermidine was first discovered by Dutch scientist Antonie van Leeuwenhoek in 1678 in human semen, which is where it gets its name from . But don't worry, spermidine supplements aren't from the same source. In fact, spermidine exists in various foods, making it accessible through everyday diet.
In the human body, spermidine levels naturally decline with age, which has led to increased interest in its potential as a dietary supplement.
Foods High In Spermidine 
|Spermidine Content (nmol/g)
|Legumes and Soybean Products
|Nuts and Oilseeds
|Fresh Fish and Seafood Products
|Cured and Fermented Meat and Derivatives
|Semi-preserved and Canned Fish and Cooked Meat Derivatives
Potential Spermidine Benefits
As we look closely at spermidine benefits, especially regarding age-related diseases, it's important to remember that our discussion is based on preliminary research findings that provide a glimpse into how spermidine may contribute to health and a healthy aging process.
Please remember that this is an overview of current research and not a definitive guide.
1. Spermidine and Autophagy (Cellular Renewal)
Autophagy is a vital cellular process in which the body systematically removes damaged cells, critical to maintaining cellular health and functionality. This process is crucial for preventing the buildup of cellular waste and ensuring the efficient operation of cells, and spermidine induces autophagy.
In the context of aging, autophagy is particularly significant as it helps combat the natural deterioration of cells, and spermidine has been linked with the process of autophagy .
So, what does this imply? Spermidine and spermine (another polyamine) are essential to metabolic pathways for vital metabolic pathways such as cell growth, proliferation, RNA and DNA stability, and immune responses.
Research has shown that spermidine prolongs the lifespan of several organisms, including fungi, nematodes, insects, and rodents.
In animal models, spermidine supplementation has been observed to delay the onset of age-associated disorders such as cardiovascular diseases and neurodegeneration. This makes spermidine a compelling subject for aging research. Its ability to induce autophagy is a crucial aspect of its anti-aging effects. However, its impact may extend beyond autophagy to other geroprotective mechanisms (aging process) .
2. Spermidine and Brain Health
Decreased cognitive performance is a common aspect of brain aging.
In animal models, dietary spermidine has been shown to pass the blood-brain barrier, enhancing hippocampal function, which is crucial for memory and learning. Specifically, spermidine feeding in aged mice improved spatial learning and increased hippocampal respiratory competence.
In a Drosophila aging model, spermidine boosted mitochondrial respiratory capacity, an effect linked to autophagy regulation. These findings suggest that maintaining mitochondrial and autophagic function is essential for the cognition-enhancing effects of spermidine .
Ongoing research, including clinical trials, continues to investigate its effects and mechanisms, aiming to provide more conclusive evidence for its use in enhancing cognitive function and potentially preventing age-related cognitive diseases.
3. Spermidine and Cardiovascular Benefits
There has been some ongoing research on the potential of spermidine on cardiovascular disease and cancer.
Spermidine is being studied for its potential effects on various aspects of health. Research in animal models has explored how spermidine might influence processes like autophagy, mitophagy, and mitochondrial respiration, which are like maintenance and energy systems for our cells. .
These mechanisms work collectively to contribute to the overall health of the cardiovascular system, which could reduce the risk of heart-related diseases and aid in the longevity of heart cells.
While these studies are promising, they are inconclusive evidence that spermidine can prevent or treat cardiovascular diseases or cancer.
4. Spermidine and Immune Function
Spermidine plays an important role in regulating the immune system. It has been found to reduce the production of proinflammatory cytokines and inflammation by modulating macrophages in various inflammation models.
Spermidine seems to positively affect various immune cells, such as CD8+ T-cells, regulatory T-cells (Tregs), and B-cells.
These cells are essential for our body's defense system. By enhancing the function of these cells, spermidine might help slow down immunosenescence, which is the weakening of the immune system that happens as we get older, at least in mice studies .
While spermidine is generally considered safe, adhering to recommended dosages is key. Overconsumption could lead to digestive issues or other side effects.
Another thing you should be wary of is the quality of the spermidine you're using. As a general rule of shopping, you should shop your spermidine supplements from trusted brands with a proven track record for quality and customer satisfaction with third-party lab reports that provide the purity and potency of the active ingredients.
For those with a health condition and are on medications, please consult a healthcare provider before starting any new supplement.
The Takeaway: Spermidine Benefits For The Aging Process
As we age, the natural spermidine levels in our bodies tend to decline. This decrease is noteworthy because spermidine plays a crucial role in various cellular functions.
Spermidine is involved in processes like autophagy, which helps cells remove damaged components and maintain cellular energy through mitochondrial function. The reduction in spermidine levels can impact these essential cellular activities necessary for overall health and graceful aging.
Spermidine might not be as well-known as resveratrol or racetams in the space of longevity supplements yet — but the research we've laid out shows that this is a promising compound with potential benefits for the aging process.
Maintaining adequate spermidine levels, either through diet or supplements, might be beneficial in supporting these vital cell functions as we age. Incorporating spermidine into one's routine alongside a balanced diet and exercise could be a step towards helping overall health during the aging process. However, it's always essential to consult healthcare professionals for personalized advice.
FAQs About Spermidine
Does spermidine work for weight loss?
No conclusive evidence suggests that spermidine directly contributes to weight loss.
What foods are highest in spermidine?
Foods high in spermidine include wheat germ, aged cheese, mushrooms, soy products, and whole grains.
Does spermidine help hair growth?
Not enough research provides definitive evidence that spermidine promotes or helps with hair growth.
How much spermidine should I take per day?
The optimal daily intake of spermidine has not been established, and we can't give you recommendations on how much you should take as so many factors are involved in one's supplementation needs. However, most people will take anywhere from 5-15 mg of spermidine daily as its benefits come with consistency of use.
How do you increase spermidine intake?
To increase your spermidine intake, you can add more spermidine-rich foods to your diet, like wheat germ, soy products, and aged cheese., or you can incorporate a high-quality spermidine supplement into your routine.
How much spermidine is in wheat germ?
Wheat germ is a good source of spermidine, but the exact amount can vary depending on the source and preparation. According to Frontiers in Nutrition Editorial Office, there is roughly 2437 nmol/g of wheat germ.
What is spermidine used for?
Spermidine is being researched for its potential role in cellular health and aging processes, but it is not approved for treating or preventing any specific medical conditions.
- Mendez, J. D. (2017). The other legacy of Antonie Van Leeuwenhoek: the polyamines. J Clin Mol Endocrinol, 2(1), 1-2.
- Frontiers in Nutrition Editorial Office. (2019). Spermidine in health and disease. Frontiers of Nutrition. Retrieved from https://www.frontiersin.org/articles/10.3389/fnut.2019.00027/full
- Hofer, S. J., Simon, A. K., Bergmann, M., Eisenberg, T., Kroemer, G., & Madeo, F. (2022). Mechanisms of spermidine-induced autophagy and geroprotection. Nature Aging, 2(12), 1112-1129.
- Schroeder, S., Hofer, S. J., Zimmermann, A., Pechlaner, R., Dammbrueck, C., Pendl, T., ... & Madeo, F. (2021). Dietary spermidine improves cognitive function. Cell reports, 35(2).
- Filfan, M., Olaru, A., Udristoiu, I., Margaritescu, C., Petcu, E., Hermann, D. M., & Popa-Wagner, A. (2020). Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats. Geroscience, 42, 937-949.