Imagine if you could turn the clock back on your cells — no DeLorean needed. That's what some researchers believe spermidine supplementation could achieve. One of the best spermidine sources for supplements is wheat germ, but it’s also a naturally occurring polyamine compound found in various foods, from aged cheese to hearty whole grains, and it's making a big impression in the science of cellular health and anti-aging [1 ,2].
We're here to talk about why adding a spermidine supplement to your daily routine could be as essential as your morning coffee and guide you through some of the best spermidine supplements on the market in 2024.
Part of understanding what goes into a good supplement lies in the research behind healthy aging, but we promise to keep the science as digestible as possible.
The Best Spermidine Supplements in 2024
We've sifted through the good, the bad, and the not-so-potent to bring you the real deal when it comes to the best spermidine supplements on the market to help guide shoppers through the maze of options to the ones that truly stand out.
1. Neurogan Health Spermidine Tablets
If you're looking for a solid place to start with a no-nonsense, high-quality, affordable spermidine supplement, this is it.
With a stealthy 10 mg of spermidine per serving, these sneak in a powerful dose in a tiny tablet. The blend of magnesium stearate and microcrystalline cellulose makes these tablets hold their shape but dissolve quickly while being gentle on the stomach, which means your body gets to the good stuff quicker, and who doesn't love efficiency in their wellness routine?
Our process involves the power of biosynthesis to extract pure, high-potency spermidine directly from wheat germ. This sophisticated method involves using specialized microorganisms to convert the nutrients in wheat germ into concentrated spermidine naturally.
The result? A supremely potent and pure form of spermidine, ensuring you get the maximum benefits in every dose.
By using biosynthesis, we reduce the strain on natural resources and ecosystems. It's a more ethical and environmentally friendly approach, aligning with our commitment to sustainability.
All our spermidine tablets are made in a cGMP-certified facility in San Diego with complete 3rd party testing for your safety and peace of mind.
Price: $34.00
Mg of Spermidine Per Serving: 10 mg
Count: 120 Tablets
Other Ingredients:
- Spermidine
- Magnesium Stearate
- Microcrystalline Cellulose
- Dicalcium Phosphate
- Silicon Dioxide
Pros:
- High potency of spermidine with 10 mg per tablet
- Fast dissolving
- Gentle on the stomach
- GMP-certified production
- Pure and focused formula
Cons:
- One-ingredient focus may not be comprehensive enough for some people
- Some people may find the taste or texture of tablets less palatable
2. Neurogan Health All-In-One
If supplements had a personality, our All-In-One Brain booster would be your charming, does-it-all friend for healthy aging support. Each capsule contains:
- Trans-resveratrol (150 mg)
- Fisetin (150 mg)
- Quercetin (150 mg)
- Pterostilbene (50 mg)
- Pyrroloquinoline Quinone (25 mg)
- Spermidnie (25 mg)
This All-In-One spermidine supplement is thoughtfully combined with other compounds known for their potential to support various aspects of health, which may impact one's health span alongside a healthy lifestyle. For instance, combining trans-resveratrol and spermidine may work together for even more autophagy benefits, and fisetin, pterostilbene, and PQQ provide hefty antioxidant support [3, 4, 5].
It's a simplified way to get potent doses of antioxidant compounds in a supplement regimen without taking many different pills.
Price: $40.00
Mg of Spermidine Per Serving: 25 mg
Count: 60 Capsules
Other Ingredients:
- Vegetable Cellulose (Capsule)
Pros:
- High potency of spermidine with 25 mg per capsule
- Synergistic blend
- Targets multiple aspects of health, including mitochondrial health, brain health, oxidative protection, and supporting overall wellbeing
- GMP-certified production
- The convenience of combining all these compounds into one supplement
Cons:
- Ingredient sensitivities to one or more of the ingredients
- Potential interactions with medicines
3. Double Wood's Spermidine
Double Wood's Spermidine contains 10 mg of spermidine 3HCL, or spermidine tryhydrochloride, per serving — which is the spermidine compound stabilized with hydrochloric acid. This stabilization is pretty nifty because it could help the compound's shelf-life and absorption.
The capsule is made of HPMC (hydroxypropyl methylcellulose), a plant-based alternative to gelatin, making it a thumbs-up for vegetarians. And the rice flour — while some might give side-eye to fillers, here, it's like the parsley on your dinner plate. It's not just there for looks; it helps package the spermidine neatly into the capsule and stabilizes the ingredient.
Price: $39.95
Mg of Spermidine Per Serving: 10 mg
Count: 120 Capsules
Other Ingredients:
- HPMC Capsule
- Rice Flour
Pros:
- High potency of spermidine with 10 mg of spermidine
- A stabilized form of spermidine trihydrochloride
- GMP-certified production
- Simplicity and purity in minimal ingredients
Cons:
- One-ingredient focus may not be comprehensive enough for some people
- Some people may have difficulties swallowing capsules
4. HUMANX Spermidine+
HUMANX opts for wheat germ extract as its source of spermidine, which won't be as potent as the other spermidine supplements mentioned in this list, which is why it has 998 mg of wheat germ extract per serving.
The problem some might find with this is that you know there's spermidine in wheat germ, but what is the exact amount? That's less clear.
With each serving of two capsules, you're also getting a dose of thiamine (Vitamin B1) and zinc.
Thiamine helps your body convert carbohydrates into energy. Think of it as the energy manager, ensuring your cells are well-fed and ready. It has also been found to support nerve function [6].
Now, zinc is like the immune system's personal trainer. It's vital for keeping your body's defense system strong and responsive. Zinc steps in to help with wound healing and even plays a role in your sense of taste and smell. But wait, there's more — it's also key for protein synthesis and cell growth [7].
HUMANX Spermidine+ isn't just playing a one-note tune with spermidine— it's offering a more holistic harmony by including thiamine and zinc, though it does come with a heftier price tag for an undetermined amount of spermidine in each dose
Price: $49.95
Mg of Spermidine Per Serving: unknown — but does contain 998 mg of wheat germ extract
Count: 60 Capsules
Other Ingredients:
- Thiamine
- Zinc
- Capsule not listed
Pros:
- Includes complimentary active ingredients zinc and thiamine to support nerve health and healthy aging
- Wheat germ extract may provide other nutritional benefits
Cons:
- Expensive at $49.95 for a 30-day supply
- Uncertainty in spermidine content
- Capsule size may be difficult to swallow
5. ReNue By Science Spermidine Supplement
Powdered liposomal spermidine is the star player here. Imagine spermidine getting a first-class ticket inside tiny lipid (fat) bubbles known as liposomes. This VIP treatment isn't just for show — the idea is to make the spermidine more bioavailable [8].
In simpler terms, it’s like wrapping a delicate gift (spermidine) in bubble wrap (liposomes) to make sure it gets where it needs to go in your body without any hiccups.
Each serving of two capsules packs 8 mg of this liposomal spermidine. It's not the highest dose on the block, but it’s definitely not skimping, either.
With 90 capsules in a bottle and a serving size of 2 capsules, you're looking at a 45-day supply. Here’s the part where you might raise an eyebrow.
At $49.95, it's sitting at the higher end of the spectrum, price-wise — sometimes the extra features (liposomal spermidine) justify the cost, and sometimes you’re just paying for the name. In this case, liposomal spermidine is an ingredient that costs more and could help some people make their spermidine supplementation that much more efficient.
Price: $49.95
Mg of Spermidine Per Serving: 8 mg
Count: 90 Capsules
Other Ingredients:
- D-Ribose
- Sunflower Lecithin
- Rice Flour
- Microcrystalline Cellulose
Pros:
- Liposomal delivery may help with better absorption
- 8 mg balanced dosage may suit various needs without being overly potent
- 45-day supply provides good value in terms of the duration of use
Cons:
- $49.95 is relatively expensive compared to other spermidine supplements on the market
- Potential allergen concerns in the other ingredients list
- Capsule size may be difficult to swallow
6. spermidineLIFE® Original Spermidine Supplement
Let's take a peek at spermidineLIFE® 800mg Dietary Supplement, a long-time player in the spermidine game with a loyal following. It's made a name for itself with a consistent track record of quality. But remember, just because it’s a household name doesn’t always mean it’s the best fit for everyone.
It’s for those who prefer supplements as close to Mother Nature as possible, as it contains 800 mg of wheat germ extract per serving (2 capsules). Like a chef adding a dash of secret spices, they’ve sprinkled in thiamine and zinc. Thiamine is there for that metabolic kick, while zinc plays defense for your immune system. Yes, this formula looks very similar to the Human X Spoermine but is more expensive.
The price might make you think twice, but it could be a worthy investment for those who value the brand's legacy and commitment to a natural formulation.
Price: $59.95
Mg of Spermidine Per Serving: unknown — but does contain 800 mg of wheat germ extract
Count: 60 Capsules
Other Ingredients:
- Thiamine
- Zinc
- Hypromellose
- Acetylated starch
- Calcium carbonate
- Magnesium stearate
- Glycerol
Pros:
- Natural ingredient focus with 800 mg of wheat germ extract
- Additional nutritional ingredients with zinc and thiamine
- Established reputation in the spermidine supplement space
Cons:
- High price point at $59.00 for 60 capsules — you may be paying for brand reputation
- Unknown spermidine content per dose
- Capsule size may be difficult to swallow
7. Toniiq Spermidine+ Supplement
Let's talk about Toniiq Spermidine+, the fresh face in the world of spermidine supplements. Starting with the price — at $19.97 for 60 capsules, it's a budget-friendly option for a 30-day supply.
It's not skimping on the spermidine here, either. 21 mg of spermidine trihydrochloride per serving of two capsules and 100 mg of rice germ extract may help add to the overall nutritional value of each serving.
Toniiq Spermidine+ keeps it simple. It’s like a no-frills airline ticket — you get what you need without the unnecessary extras. This straightforward approach can be appealing to those who want their supplements without complexity.
Though newer to the scene, Toniiq Spermidine+ is quickly making a name for itself, much like a breakout indie band. It’s gaining popularity, which speaks to its effectiveness and value.
Price: $19.97
Mg of Spermidine Per Serving: 21 mg
Count: 60 Capsules
Other Ingredients:
- Microsytralline Cellulose
- Hydroxypropyl Methylcellulose
- Vegetable Stearate
- Silicon Dioxide
Pros:
- Affordable pricing, making it accessible to a wider range of customers
- High spermidine content with 21 mg of spermidine and wheat germ extract
- Simple and straightforward formulation
Cons:
- Wheat germ extract doesn't have exact nutritional information or spermidine content
- Capsule size may be difficult to swallow
8. Life Force Peak NMN with Spermidine
Primarily an NMN supplement, Life Force Peak is like the jack-of-all-trades in your wellness toolkit. It doesn’t just stop at NMN; it throws in a cocktail of berberine HCL (660 mg), white mulberry extract, lithium orotate (10 mg), and a dash of spermidine (5.7 mg).
It's designed with a mission to "renew the body from the inside and out."This formula suggests support for healthy metabolism, DNA, and epigenetic function [9, 10]. The price stands at $90 a bottle, placing it in the higher-end category. It's an investment akin to choosing a premium service for its added ingredient benefits.
If your primary goal is to boost NAD+ levels and you're interested in the added benefit of spermidine, this supplement could be a fitting choice. While it offers a range of wellness potential, its price may be a consideration for those seeking more budget-friendly options. It stands out as a comprehensive choice for anyone looking to target multiple aspects of their health in one go.
Price: $90
Mg of Spermidine Per Serving: 5.7 mg
Count: 90 Capsules
Other Ingredients:
- Microcrystalline Cellulose
- Hypromellose (capsule shell)
- Magnesium Stearate
- Silica
Pros:
- Comprehensive formula for supporting DNA and epigenetic function
- Additional NAD+ boost
- Quality ingredients
Cons:
- High price point at $90 per bottle
- Complex blend might be too overwhelming to those who prefer single-ingredient supplements
- Limited spermidine content
- Capsule size may be difficult to swallow
9. Agent Nateur calm (beauty) spermidine and taurine
Agent Nateur is breaking into the luxury beauty and wellness space with skincare, makeup, and supplements that help you feel your best in your own skin.
Its calm (beauty) spermidine and taurine supplement is unlike anything else on this list — and frankly, anything else we've come across in the market. This product is designed with beauty and relaxation in mind, combining ingredients supporting cellular health and stress management.
Each 15 ml sachet is an elixer (rather than a capsule or tablet) that contains a blend of spermidine, taurine, vitamin D, B vitamins, L-theanine, 5-HTP, and tryptophan — making it a multitasking supplement, helping you achieve that serene, "calm beauty" from within.
Price: $72
Mg of Spermidine Per Serving: 1 mg
Count: 24 Sachets
Other Ingredients:
-
Vitamin D (Cholecalciferol from licen)
-
Vitamin B6 (Pyridoxine HCI)
-
Pantothenic Acid (D-Calcium Pantothenate)
-
Magnesium
-
L-Glycine
-
GABA (Gamma-Aminobutyric Acid)
-
Taurine
-
L-Theanine
-
Magnesium Citrate
-
5-HTP
-
L-Tryptophan
-
Water
-
Organic Tart Cherry Juice Concentrate
-
Glycerin
-
Malic Acid
-
Citrus Pectin
-
Natural Cherry Essense
-
Stevia
Pros:
-
Unique blend combining spermidine with other beauty and stress management ingredients
-
Designed to support stress and cellular health
-
Convenient sachets for on-the-go-use
Cons:
-
High price point at $72 per 24 servings
-
Lower spermidine content, but it is complemented by other wellness ingredients
-
This could be too complex for those seeking a simple spermidine supplement
Pure Spermidine Supplement vs. Wheat Germ or Rice Germ Extract
Spermidine supplements that list “spermidine” as the main ingredient offer spermidine in its pure form. It's usually biosynthesized for consistency and potency.
Wheat germ is the small, nutrient-rich core of a wheat kernel, which is known to be high in natural spermidine. Despite just being a tiny part of the wheat grain, it's packed with essential nutrients, and it's what would eventually grow into a new plant.
The biosynthesis process of spermidine is a cutting-edge method that transforms the natural goodness of wheat germ into a highly potent form of spermidine.
Taking a spermidine supplement is a much more straightforward approach to getting higher doses of the compound. The potential spermidine benefits include cellular renewal, gut health, brain health, and more.
Wheat germ extract or rice germ extract could be seen as a more holistic approach as they may contain other nutritional benefits from these grains, which are considered spermidine-rich foods and may be gentler on the system. However, it's not always easy to determine how much spermidine you're getting with each of these types of dietary supplements.
Best time to Take Spermidine Supplement
When it comes to taking spermidine supplements, timing is everything — and we're talking about both the 'when' in your life and the 'when' in your day.’ Let’s break it down, shall we?
Best Age to Start Spermidine Supplements
There's no magical age where a giant neon sign says, “Start your spermidine now!” But, as with many good things in life, starting earlier rather than later can have its benefits.
Think of spermidine like a good skincare routine — you don’t wait for the wrinkles to appear before moisturizing. So, if you’re pondering when to start incorporating spermidine into your wellness regimen, consider this: the sooner, the better.
Let’s say you’re in your late twenties or early thirties.
It's that sweet spot in life where you start thinking about investing in your future — not just financially.
This is often the prime time people consider spermidine's support seriously. Think of it as a proactive approach to wellness, like starting a retirement fund for your cells. You're laying the groundwork for a healthier, more vibrant you in the years to come.
Time of Day Spermidine Schedule
Moving on to the daily ‘when.’ Some folks swear by taking their spermidine supplement in one go during the day — like a power breakfast for your cells.
Others prefer to split their spermidine servings, one in the morning and one at night. This approach is like bookending your day with some goodness — a morning kickstart and an evening wind-down.
So, what’s the best approach? It's like choosing between coffee and tea — it depends on what works for you. The key is consistency.
Spermidine Supplement Safety
Generally, spermidine is considered safe for most people, but there are a few important guidelines to remember [11].
First and foremost, stick to the spermidine dose outlined on the product label. Adhering to the recommended dosage helps to ensure you're not going overboard on spermidine or any other of the additional ingredients.
If you have any existing health conditions, consult with a healthcare professional before starting spermidine supplements. They can provide personalized advice and help you understand how spermidine affects your health status or medications.
Always review the ingredient list for potential allergens. Spermidine supplements can vary in composition — some might include ingredients that could trigger allergic reactions. It's like checking a food package for ingredients you’re allergic to — better safe than sorry.
Keep in mind that spermidine supplements are just that — supplements. They're meant to complement your diet, not replace any aspect of your prescribed health regimen.
The Best Wheat Germ of Spermidine
For those who like their supplements as Mother Nature intended, we'll highlight the best wheat germ options for your spermidine needs. Sure, biosynthetic spermidine is safe, derived from natural ingredients, and eco-friendly, but for some, there's something about sticking to the traditional roots that feels right, too.
Here are the top choices on our list for wheat germ extract spermidine:
- HUMANX Spermidine+
- spermidineLIFE® Original Spermidine
- Toniiq Spermidine+ Supplement
The Takeaway: Best Spermidine Supplement in 2024
Whether you want the whole nine yards or just the essentials, something in our top eight will strike the right chord. It's all about finding that supplement that syncs with your lifestyle and budget.
Each of these eight contenders has its personality with pros and cons that could point you in the right direction in your wellness journey.
What makes them shine? It's their meticulous care in product formulation and the trustworthiness that each brand exudes.
FAQs
What does spermidine do?
Spermidine is a naturally occurring compound that has been studied for its potential role in cellular processes like autophagy, which involves the renewal and recycling of cells.
Does spermidine help with weight loss?
As of now, spermidine's effects on weight loss have not been extensively studied. Therefore, it cannot be recommended specifically for weight loss purposes.
How much spermidine should I take?
While we don't provide specific dosage recommendations to suit a health goal, most research on spermidine has observed effects within the 5-15 mg range. It's been found to be safe and well-tolerated even in higher doses. However, it's always best to consult a healthcare provider to determine the right amount for your needs.
What foods are high in spermidine?
Foods high in spermidine include aged cheese, mushrooms, whole grains, legumes (like lentils and soybeans), and certain fruits and vegetables. Including a variety of these foods in your diet can naturally increase your spermidine intake.
Resources:
- Shi, Y. J., Zhang, J., Wang, Y. W., Ding, K., Yan, Y., Xia, C. Y., ... & Xu, J. K. (2022). The untapped potential of spermidine alkaloids: Sources, structures, bioactivities and syntheses. European Journal of Medicinal Chemistry, 240, 114600.
- Madeo, Frank, Tobias Eisenberg, Federico Pietrocola, and Guido Kroemer. "Spermidine in health and disease." Science 359, no. 6374 (2018): eaan2788.
- Morselli, E., Mariño, G., Bennetzen, M. V., Eisenberg, T., Megalou, E., Schroeder, S., ... & Kroemer, G. (2011). Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. Journal of Cell Biology, 192(4), 615-629.
- Mikstacka, R., Rimando, A. M., & Ignatowicz, E. (2010). Antioxidant effect of trans-resveratrol, pterostilbene, quercetin and their combinations in human erythrocytes in vitro. Plant foods for human nutrition, 65, 57-63.
- Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant for health promotion. Antioxidants & redox signaling, 19(2), 151-162.
- Lonsdale, D. (2006). A review of the biochemistry, metabolism and clinical benefits of thiamin (e) and its derivatives. Evidence-Based Complementary and Alternative Medicine, 3, 49-59.
- Lansdown, A. B., Mirastschijski, U., Stubbs, N., Scanlon, E., & Ågren, M. S. (2007). Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound repair and regeneration, 15(1), 2-16.
- Maghsoudnia, N., Edalat, M., Hajimolaali, M., Iranpour, S., Khoshkhat, P., Inanloo, P., ... & Dorkoosh, F. A. (2022). Liposomal Supplements. In Liposomes for Functional Foods and Nutraceuticals (pp. 235-278). Apple Academic Press.
- Ye, Y., Liu, X., Wu, N., Han, Y., Wang, J., Yu, Y., & Chen, Q. (2021). Efficacy and safety of berberine alone for several metabolic disorders: a systematic review and meta-analysis of randomized clinical trials. Frontiers in pharmacology, 12, 885.
- Lown, M., Fuller, R., Lightowler, H., Fraser, A., Gallagher, A., Stuart, B., ... & Lewith, G. (2017). Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a randomised double-blind placebo-controlled study. PLoS One, 12(2), e0172239.
- Schwarz, C., Stekovic, S., Wirth, M., Benson, G., Royer, P., Sigrist, S. J., ... & Flöel, A. (2018). Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY), 10(1), 19.
