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Image of a copper peptide dropper: Copper Peptite (GHK-CU) dosage

Copper Peptide (GHK-Cu): Dosage, Safety, and More

Peptides, particularly copper peptides (GHK-Cu), consisting of a small peptide, Glycyl-L-Histidyl-L-Lysine (GHK), and copper ions (Cu), have become a focal point in the health and beauty industries for their multifaceted potential benefits, from hair and skin rejuvenation to possibly playing a role in maintaining overall health with age.

In this article, we'll look at the research surrounding copper peptides, exploring their dosages and the different methods of GHK-Cu therapy to address hair growth, skin firmness, and more. 

While we will be unpacking the current research surrounding the potential benefits of GHK-Cu for wound healing, skin density, hair growth, and anti-aging, this is by no means an article that recommends using copper peptides as a cure or treatment for any health condition. 

More importantly, just because you can purchase medical-grade, injectable, naturally occurring copper complexes online doesn’t mean you should inject them into your body alone. 

The Food and Drug Administration (FDA) has not approved the direct recommendation of copper peptides for therapeutic use without a prescription.

This is purely intended to quench your curiosity about this exciting natural complex and give you a foundation for understanding so that you can ask your healthcare professional for tailored advice to suit your needs.

With that out of the way, let's get into it.

Overview Benefits of GHK-Cu

While direct medical treatments and benefits are still under research and not FDA-approved, here’s a look at the promising aspects of GHK-Cu:

  • Hair Growth Potential: GHK-Cu is noted for its potential to stimulate hair follicles, possibly leading to improved hair growth. This makes it an area of interest for those looking into solutions for thinning hair.
  • Wound Healing/Skin Regeneration: Preliminary studies suggest GHK-Cu might play a role in enhancing wound healing and promoting the regeneration of skin cells. Its potential to support the body's natural healing processes makes it a compound of interest in skincare.
  • Skin Firmness: GHK-Cu has improved skin elasticity and firmness. Boosting collagen production helps reduce the appearance of fine lines and wrinkles, contributing to a more youthful skin appearance.

GHK-Cu Peptide Injection Dosage

syringe inserted into GHK-Cu solution bottle

GHK-Cu injections have been explored for several therapeutic and cosmetic applications driven by their potential for hair growth, skin rejuvenation, wound healing, and anti-inflammatory effects [1, 2,]. 

There's no one approach to GHK-Cu injection dosages — how much is given is based on the specific GHK-Cu formulation, the size of the area being treated, individual health conditions, and the purpose of the treatment.

The availability of GHK-Cu injectables online has made them accessible to more people, but just because you can find injectable copper peptides online doesn't mean you should DIY this. 

Self-administration of any injectable carries significant risks like infection, allergic reactions, and the impairment of nervous system function.

It's strongly recommended that any GHK-Cu injection treatment be conducted under the supervision of a qualified healthcare professional, ideally in a clinical setting. Medical professionals can ensure the treatment is appropriate for the individual's health status, manage the correct dosage, and minimize the risks associated with injections.

GHK-Cu Injection Dosage for Hair Growth

Man getting a heir injection

In clinical settings or studies focusing on hair growth, GHK-Cu dosages have not been universally standardized. Still, some research protocols have administered GHK-Cu in concentrations ranging from 0.1% to 1.0% in injectable topical application solutions [1].

When it comes to injections, dosages might be adjusted based on the area of the scalp treated, with careful consideration given to the depth and spacing of injections to maximize the peptide's reach to hair follicles. 

However, specific dosages for subcutaneous injections aiming at hair growth stimulation are less commonly detailed in the publicly available research literature.

GHK-Cu Injection Dosage for Skin Healing and Rejuvenation

Woman close up to forehead getting a microneedling treatment

GHK-Cu is also promising for its skin healing and rejuvenating properties. It's thought to promote collagen and elastin production, improve skin elasticity, and diminish fine lines and wrinkles. This makes it a popular choice for people looking to address aging skin in clinical settings.

For injectable solutions, concentrations may again range from 0.1% to 1.0% (10 mg in 5 mL vials or 5 mg in 5 mL vials), adjusted according to the treatment plan and the size of the area being treated.

Treatments might be spaced over several sessions, with the total dosage spread out to monitor and evaluate the skin's response.

A personalized treatment plan is essential for harnessing the full potential of GHK-Cu injections. This involves not only adjusting dosages but also integrating other modalities as necessary.

Micro-needling, a procedure that involves creating tiny punctures in the skin using micro-fine needles, naturally stimulates the body's wound healing response, leading to increased collagen and elastin production. When GHK-Cu is applied to the skin in conjunction with micro-needling, the theory is that the benefits of both treatments are enhanced.

While micro-needling can be done at home with devices designed for consumer use, applying GHK-Cu professionally ensures the correct technique, sterilization, and product quality. This minimizes the risk of infection and maximizes the treatment's benefits.

GHK-Cu Skin Care Dosage

Closeup to blue cream

In formulating skin care products containing GHK-Cu, concentration levels are based on the intended frequency of use and specific skin areas targeted by the product. This peptide is typically found in 2% to 10% concentrations to optimize efficacy while minimizing the risk of skin irritation.

For products intended for daily application, such as morning and evening routines, we use a concentration of 4% GHK-Cu for our face and neck serums and creams.

This concentration is designed to effectively promote skin health, including enhancing collagen production and reducing the appearance of fine lines, while being gentle enough for regular use on most skin types.

The rationale behind this concentration choice is grounded in the balance between delivering tangible skin benefits and maintaining skin integrity without causing adverse reactions.

A lower concentration of 2% GHK-Cu is used in our eye serums for the delicate area around the eyes. This approach aligns with the principle of targeted therapy in dermatological science, where the dosage and formulation are adjusted to the specific needs and tolerance of different skin regions.

By adjusting the GHK-Cu dosage according to product use frequency and targeted skin areas, these skincare solutions are engineered to maximize the peptide's regenerative properties while ensuring user safety and comfort. This scientific approach to skincare formulation underscores the commitment to leveraging bioactive compounds effectively and responsibly in dermatology.

Ingestable GHK-CU Dosage

Close up to a hand holding a white round tablet

When applied topically, copper peptides are becoming popular for their skin-rejuvenating properties. But what happens when we explore their benefits from the inside out?

From keeping our red blood cells in shipshape to energizing our day and supporting our brain, copper plays a pivotal role. GHK-Cu offers a form of copper eager to get to work, potentially amplifying these essential benefits throughout our bodies.

The golden question of how much GHK-Cu to take is still for scientific debate. Since we’re all unique, the ideal dosage might vary from person to person, considering factors like age, lifestyle, and health objectives. Plus, ensuring that GHK-Cu is effectively absorbed and put to good use by our bodies is a puzzle researchers are diligently working to solve.

The Takeaway: GHK-Cu Dosage

Blue liquid dropper

GHK-Cu, a copper peptide known for its potential in tissue repair, anti-aging, and health promotion, represents a frontier in wellness and medical science. Yet, the path to integrating such compounds as injectables into our health regimen is paved with caution, especially in the absence of definitive clinical guidelines on dosages for injection or ingestion.

We have a lot more flexibility regarding topical applications such as creams and serums. At concentrations of 4% for the face and neck, we found that this is gentle enough to support the skin’s natural processes for repair. We opted for a  2% concentration for our eye serum as the skin around the eyes is much more delicate and sensitive to active ingredients.

However, in the spirit of responsible use and adherence to FDA guidelines, we acknowledge the current limitations in our understanding, particularly regarding precise dosages. 

The complexity of bioactive compounds like GHK-Cu and their systemic effects mean that "one-size-fits-all" dosages are not feasible. Individual health status, potential interactions, and specific health goals must all be considered when determining the appropriate use of GHK-Cu, whether through injections or ingestible forms.

Consulting with healthcare providers ensures that any application of GHK-Cu is tailored to the individual, mitigating risks and aligning with the best available scientific evidence.


  1. Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International journal of molecular sciences, 19(7), 1987.
  2. Maquart, F. X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J. C., & Borel, J. P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide‐copper complex glycyl‐L‐histidyl‐L‐lysine‐Cu2+. FEBS letters, 238(2), 343-346.
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Katrina Lubiano

Based in Canada, Katrina is an experienced content writer and editor specializing in health and wellness. With a journalistic approach, she's crafted over 900,000 words on supplements, striving to debunk myths and foster a holistic approach to healthi...

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