Many skin experts are excited about copper peptides as an important element for supporting a youthful skincare routine. According to research, these small chains of amino acids (peptides) combined with copper ions (Cu2+) show significant potential in supporting collagen and elastin production and anti-inflammatory actions that support wound healing and hair growth and provide anti-aging benefits [1].
In this article, we'll dive deeper into the scientific studies surrounding copper peptides and their benefits for the skin and hair. We'll uncover why these powerful compounds have become a cornerstone in the wellness routines of those seeking to enhance their skin's appearance and support health from within.
How Do Copper Peptides Work?
Copper peptides operate on a cellular level, influencing various physiological pathways and contributing to their benefits.
Stimulating Collagen and Elastin Production
Copper peptides contribute to synthesizing collagen and elastin, two proteins responsible for the skin's structural integrity and elasticity, by activating the skin’s fibroblasts, the cells responsible for producing these proteins. The process is facilitated by copper's ability to act as a cofactor for lysyl oxidase, an enzyme crucial for cross-linking collagen and elastin fibers, enhancing skin strength and elasticity [2].
Anti-Inflammatory Actions
Copper peptides are found to modulate the inflammatory response by downregulating pro-inflammatory cytokines, which are cell signaling proteins that can exacerbate inflammation and damage [3].
Enhancing Angiogenesis
Copper peptides support the skin's structural components and promote angiogenesis—forming new blood vessels from pre-existing ones, which is a big part of healthy wound healing [4].
Copper Peptide Benefits
By understanding a little bit more about how they work, we can start to piece together some of the wellness benefits of copper peptide serums and therapies.
Hair Growth
Copper peptides have been shown to stimulate the hair follicles, potentially turning the tide against hair thinning and loss. They provide the scalp with a nurturing environment that promotes healthy hair growth with anti-inflammatory effects and enhances follicular health.
It doesn't work for all types of hair loss, however. It seems particularly beneficial for hair loss from scalp inflammation, post-partum hair loss, and telogen effluvium (thinning hair from follicles entering the resting phase) [5].
Fine Lines and Wrinkles
By promoting collagen and elastin production, copper peptides offer a natural way to combat the signs of aging. The increased collagen production helps to firm the skin, reducing the appearance of fine lines and wrinkles for more youthful skin [2].
For this very reason, you'll see many skincare products that include copper peptides for aging skin. For more intensive treatments, copper peptides are offered at skin care clinics alongside microneedling therapy to deliver the benefits of copper peptides deeper into the layers of skin to kickstart the skin's natural collagen and elastin production.
Scars and Wound Healing
The healing powers of copper peptides extend to wound care, accelerating the skin's repair process. Their anti-inflammatory properties reduce scarring and facilitate the healing of cuts, burns, and other skin injuries.
Its properties for stimulating collagen production aid in wound closure and strength. Enhanced collagen production speeds up the healing process and ensures the formation of less noticeable scars.
Remember how we talked about angiogenesis?
The formation of new blood vessels is essential for delivering nutrients and oxygen to the wound site, further accelerating healing.
For wound healing, copper peptides are typically applied topically in the form of serums, gels, or creams formulated specifically for post-injury skincare or incorporated into dressings designed to maintain a moist wound environment.
These topical applications directly deliver copper peptides to the injury site, ensuring that the affected area fully benefits from their healing properties.
Acne and Skin Clarity
Copper peptides can also be a boon for acne-prone skin. Their anti-inflammatory and antimicrobial properties help to soothe inflamed skin and fight off acne-causing bacteria, reducing breakouts and improving skin clarity.
Many over-the-counter (OTC) skincare products incorporate copper peptides due to their benefits for acne-prone skin. These include serums, creams, and targeted treatments designed to reduce inflammation and microbial growth. Effective OTC copper peptide products often combine these peptides with other acne-fighting ingredients, such as salicylic acid, which exfoliates the skin and clears pores, and niacinamide, which improves skin barrier function and reduces inflammation.
In-clinic procedures that use copper peptides can offer more intensive treatment options for more persistent or severe acne with microneedling.
Copper Peptides' Side Effects
While copper peptides have many benefits as an active ingredient, there are also bound to be some side effects. Luckily, this compound is generally safe and well tolerated, but some side effects can include irritation, redness, and general sensitivity, especially in high concentrations or if they have sensitive skin.
Are Copper Peptides Safe?
Yes, copper peptides are safe for most people when used as directed in skincare and haircare products. However, it's always recommended to conduct a patch test or consult a dermatologist, especially for sensitive skin.
When Can You Use Copper Peptides
Copper peptides can be incorporated into your daily skincare routine, preferably at night when the skin's natural repair processes are most active. However, they can also be used during the day, provided you follow up with sunscreen to protect the skin.
Copper Peptide Dosage
Starting with a low concentration and gradually increasing, it allows your skin to adapt without experiencing adverse effects.
We have a 4% Copper Peptide Face and Neck Serum and Face and Neck Cream that's gentle enough for everyday use while providing some of the compound's potential benefits for healthy skin aging. We recommend our 2% Copper Peptide Eye Serum for more sensitive skin and around the eyes.
Ingesting Copper for Health
Copper peptides are specifically designed and most effective when applied topically to target skin and hair issues directly. Using copper in an ingestible form usually focuses on addressing copper deficiency in the body rather than providing the cosmetic benefits associated with topical copper peptide applications.
Combining Copper Peptides with Other Actives
Copper peptides can be mixed with most skincare ingredients, but they pair exceptionally well with antioxidants like vitamins C and E, hyaluronic acid for hydration, and retinol for enhanced anti-aging effects.
However, avoiding mixing them with strong acids, like glycolic acid, is crucial, as they can break down the peptides and reduce their efficacy.
The Takeaway: Copper Peptides Benefits
The versatility of copper peptides allows for over-the-counter products and in-clinic procedures, making them accessible for anyone looking to improve their skin and hair health.
While topical application is the most effective and common method of copper peptides, it's important to approach any form of supplementation with caution and under professional guidance to avoid adverse effects.
As we've explored, healthier skin and hair aren't solely reliant on a single miracle ingredient but rather a comprehensive approach that includes understanding the underlying mechanisms and choosing the right treatments and products.
Whether you're combatting the signs of aging, looking to improve wound healing, or seeking solutions for hair loss and acne, copper peptides are an option worth exploring. As with any skincare or haircare regimen, patience and consistency are key. Incorporating copper peptides into your routine could very well be the step that leads to visible, lasting improvements, bringing you closer to achieving your goals of radiant skin and healthy hair.
FAQs
Do copper peptides work?
Yes, copper peptides have been shown to support skin health by promoting collagen production, reducing the appearance of fine lines and wrinkles, and aiding in wound healing. There's also some evidence to support its role in maintaining hair health and promoting healthy wound healing [1].
Are copper peptides safe?
Yes, copper peptides are generally considered safe for most people when used as directed in skincare products. It's always recommended to perform a patch test before using a new product extensively.
Can I use Argireline with copper peptides?
You can use Argireline (a peptide known for its anti-wrinkle effects) with copper peptides in your skincare routine. They work well together to reduce the appearance of wrinkles and fine lines.
What can you use with copper peptides?
Copper peptides can be used with most skincare ingredients, including antioxidants like vitamins C and E, hyaluronic acid for hydration, and retinol for anti-aging benefits. Still, you may want to avoid using them at the same time. Wait 10-15 minutes between applications to avoid disrupting each active compound's benefits. Avoid using them with strong acids, which may reduce their effectiveness.
What do copper peptides do for the skin?
Copper peptides help rejuvenate the skin by supporting collagen and elastin production, reducing inflammation, enhancing wound healing, and providing antioxidant protection, contributing to improved skin texture and reduced signs of aging.
Resources:
- Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International journal of molecular sciences, 19(7), 1987.
- Ryvkin, F., & Greenaway, F. T. (2004). A peptide model of the copper-binding region of lysyl oxidase. Journal of inorganic biochemistry, 98(8), 1427-1435.
- Caetano‐Silva, M. E., Rund, L. A., Vailati‐Riboni, M., Pacheco, M. T. B., & Johnson, R. W. (2021). Copper‐Binding Peptides Attenuate Microglia Inflammation through Suppression of NF‐kB Pathway. Molecular Nutrition & Food Research, 65(22), 2100153.
- Xie, H., & Kang, Y. J. (2009). Role of copper in angiogenesis and its medicinal implications. Current medicinal chemistry, 16(10), 1304-1314.
- Pyo, H. K., Yoo, H. G., Won, C. H., Lee, S. H., Kang, Y. J., Eun, H. C., ... & Kim, K. H. (2007). The effect of tripeptide-copper complex on human hair growth in vitro. Archives of pharmacal research, 30, 834-839.
