NMN, or nicotinamide mononucleotide, is a precursor compound that supports NAD+ levels in the body. NAD+ (nicotinamide adenine dinucleotide) is important for virtually all cellular processes, including DNA repair and energy production — and, by extension, maintaining cellular health as we age.
In 2022, the Food and Drug Administration (FDA) took NMN off the shelves as a dietary supplement due to its investigation as a new drug for anti-aging.
This led many brands to pivot to other NAD+ precursors, such as nicotinamide riboside (NR). However, NMN supplements are still available if you know where to look.
In this article, we’ll explore the benefits of NMN, review the top NMN brands, and provide guidance on choosing the best NMN supplement for your needs.
How Effective is NMN Supplementation?
Scientific research has demonstrated that oral NMN supplements, with dosages of up to 300 mg/kg, improved muscle function, insulin activity, and mitochondrial function in older adults [1].
Another study found that NMN supplementation could improve aged mice's cognitive function and physical performance [2]. This suggests that NMN may support healthy aging by enhancing cellular function and energy metabolism. However, we must highlight that the FDA hasn't approved any NMN supplement to treat, mitigate, or cure any conditions.
There's still no conclusive evidence proving NMN is an anti-aging drug. Still, intriguing research shows its potential health benefits for cellular health overall by supporting NAD+ levels, which naturally decline as we age.
Even if you get your hands on a high-quality supplement, you shouldn't expect therapeutic results. If you have a health condition, you must speak with your healthcare provider before adding a new supplement.
Best NMN Supplement Brands
Neurogan Health
Our company specializes in wellness supplements that support cellular health for healthy aging in collaboration with researchers from Aalborg University to bring our customers safe, high-quality health supplements based on current scientific research.
All our products are produced in our GMP (Good Manufacturing Practices) facility in San Diego and tested by an accredited third-party lab to ensure they contain all the good stuff and are free from harmful contaminants.
We're proud to offer NMN supplements in various formats, from capsules, gummies, and drops, to cater to different dietary supplement regimens at the most affordable price point for potency.
More importantly, our formulations take into account the low bioavailability of NMN — it's known to have a poor rate of absorption due to its molecule size and nature — which is why we've formulated high potency and liposomal NMN to help deliver NMN into the bloodstream and protect it from digestive breakdown.
Perhaps best of all, we've found ways to maintain low price points for our NMN supplements because we produce, fulfill, and ship everything in-house, passing the savings of needing third-party services on to you.
While you can shop most of our wellness supplements on Amazon, you can only order our NMN supplements on our website due to Amazon's regulations on NMN. But we do same-day or next-day shipping and offer a 30-day money-back guarantee on all our products.
ProHealth
ProHealth is a reputable name in the dietary supplement market with a long track record for providing high-quality, science-backed products.
It has a wide range of NMN supplements that are also produced in a GMP-certified facility and tested by third-party labs. You can find NMN tablets, capsules, powders, and lozenges on only on ProHealth's website because of strict FDA regulations on NMN supplement sales in-stores and on platforms like Amazon.
ReNue By Science
ReNue By Science, founded in 2017, is considered one of the leading brands in NMN supplements. It was one of the first to produce NMN capsules in liposomal form to enhance bioavailability and absorption.
On its website, NMN supplements are available in capsules, gels, nasal sprays, and drink powders to suit different supplement preferences.
Like Neurogan Health and ProHealth, ReNue produces all products in GMP-certified facilities and opts for third-party lab testing. These should be given in the industry, but they're often not done by many supplement manufacturers.
DoNotAge
This company wasn't on our radar initially until we did further research into popular NMN brands on forums like Reddit. DoNotAge offers pure capsules and powders of compounds that are found to support cellular health, such as NMN, Ca-AKG, and CoQ10.
Its NMN supplements are sourced from high-quality raw materials and undergo heavy quality control processes. DoNotAge is committed to transparency and provides certificates of analysis for their products.
OMRE
OMRE is another promising newcomer in the wellness sector, and it caught our attention on Reddit. Despite being a newer brand, OMRE has made a significant impact by focusing on the synergistic benefits of NMN and resveratrol—two compounds known for their complementary effects on cellular health.
OMRE’s NMN supplements are meticulously crafted to ensure maximum efficacy and purity. Produced in GMP-certified facilities, each batch is subjected to rigorous third-party testing to verify the absence of contaminants and provide the highest quality standards.
Many users appreciate OMRE’s transparency, customer-focused approach, and dedication to producing high-quality supplements. The positive word-of-mouth from these communities has helped OMRE establish a strong reputation among health enthusiasts.
Other NAD+ Supplement Brands
Because of the FDA crackdown on NMN supplements for research into its potential as an anti-aging drug, many brands have shifted their focus to other NAD+ precursors, compounds that the body will transform into NAD+.
Here are some of the top brands that, in our opinion, are doing it right when producing high-quality NAD+ supplements:
- Elysium Health
- Life Extension
- Tru Niagen
- Neurogan Health
Elysium Health
Elysium Health is a well-known brand in the NAD+ supplement market as a pioneer in antiaging research. The brand primarily supports biological age and promotes longevity through evidence-based solutions. Elysium Health collaborates with world-renowned scientists and institutions to develop supplements that target the fundamental mechanisms of aging.
One of Elysium Health’s flagship products is Basis, a supplement that combines nicotinamide riboside (NR) and pterostilbene. These two compounds work synergistically to support cellular health and maintain biological age.
Elysium Health also emphasizes the importance of clinical testing. Their products undergo rigorous clinical trials to validate their safety and effectiveness. For instance, the efficacy of Basis has been demonstrated in peer-reviewed studies, showcasing its ability to increase NAD+ levels and support healthy aging.
Life Extension
Life Extension's motto is "The Science of a Healthier Life." It specializes in supplements that support brain health and energy levels for optimal health. One of its standout offerings is the NAD+ + Cell Regenerator™ supplement, which combines a trademarked version of nicotinamide riboside called Niagen and resveratrol called Resveratrol Elite, both designed to enhance their oral bioavailability.
Combining Niagen (NR) and Resveratrol Elite in Life Extension's supplement creates a powerful synergy for supporting cellular health and longevity. By boosting NAD+ levels with NR and enhancing sirtuin activity with resveratrol, this formulation aims to address multiple pathways involved in the aging process.
Transparency is another cornerstone of Life Extension's approach. The brand provides detailed information about the ingredients, sourcing, and scientific research behind their products. This transparency helps consumers make informed decisions about their health and trust in the efficacy of Life Extension's supplements.
Tru Niagen
Tru Niagen is the brand that was founded and trademarked Niagen (NR). Tru Niagen has set the standard for NR supplements designed to be better absorbed orally.
Tru Niagen's commitment to scientific research is one of the brand's defining characteristics. The company collaborates with leading scientists and research institutions to conduct extensive studies on the safety and efficacy of Niagen. These studies have demonstrated that Niagen can significantly increase NAD+ levels within as little as two weeks of supplementation.
Tru Niagen has earned the trust of health enthusiasts, athletes, and researchers worldwide. Its supplements are widely used by those looking to support their cellular health and enhance their overall well-being. The brand's dedication to scientific research, quality, and transparency has positioned it as a leader in the NAD+ supplement market.
How to determine the best NMN Brand
How did we select the best NMN supplements on our list? Here's an overview to help you navigate the health and wellness sector when shopping for supplements.
Reviews
Genuine customer reviews are a great resource when choosing an NMN supplement. Look for brands with positive feedback regarding effectiveness, quality, and customer service.
These give tremendous insight into what you can expect from a brand's services and the quality of its products.
Supplement Facts
Examine the facts about the supplement to ensure you’re getting a high-quality product.
Look for information on the dosage, purity, and additional ingredients. Opt for brands that provide third-party testing results to verify the potency and safety of their products.
NMN and other NMN precursors don't actually need any fillers or additives, as they're fairly stable on their own. Some products use liposomal formulation, which helps to improve the absorption of the active compounds, which means you may not need a dosage as high as the pure form.
That being said, make sure your products are free from harmful extras that might be doing more harm than good for your health routine.
Price
Consider the price of the supplement, as well as its quality and dosage. While cheaper options may be tempting, they may not offer the same purity and efficacy as more expensive brands. Balance affordability with quality to ensure you’re getting the best value.
Remember that consistency is the best way to use NMN supplements to maintain optimal health. It's not a one-time fix-all supplement.
Check to see if the company offers subscription services that can help you save more on our products in the long term.
Benefits
Evaluate the potential benefits of the NMN supplement based on scientific research and customer feedback. Look for products that support your specific health goals, such as improved energy levels, cognitive function, or muscle performance.
The Takeaway: The Best NMN Brands
In 2024, finding high-quality NMN supplements can be challenging because the FDA has taken so many brands off the shelves.
However, several reputable brands still offer safe and effective NMN supplements online. Neurogan Health, ProHealth, ReNue By Science, DoNotAge, and OMRE are among the best options for those looking to boost their NAD+ levels and support healthy aging.
Resources:
- Shade, C. (2020). The science behind NMN–A stable, reliable NAD+ activator and anti-aging molecule. Integrative Medicine: A Clinician's Journal, 19(1), 12.Chicago
- Tarantini, S., Valcarcel-Ares, M. N., Toth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., ... & Ungvari, Z. (2019). Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox biology, 24, 101192.
