Nicotinamide mononucleotide (NMN) supplements are being looked at for a number of potential health benefits — most notably, for its potential to support healthy aging as a precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme that all our cells use for energy metabolism, repair, and many other vital cellular tasks.
We must highlight that no NMN supplements are approved by the Food and Drug Administration (FDA) to treat or prevent aging or any diseases, for that matter, which means the topics we'll be discussing in this article aren't intended to replace the advice of your health care professional.
This is purely for quenching some curiosity surrounding NMN dietary supplements and their potential wellness benefits.
NMN Benefits
The hype surrounding nicotinamide mononucleotide (NMN) comes from its ability to convert into NAD+, an essential component of cellular health.
NMN supports healthy aging by boosting NAD+ levels, which aids in cellular repair, DNA maintenance, and mitochondrial function. This can enhance energy production, help regulate metabolism, and potentially improve exercise performance. While more human research is needed, studies suggest NMN could play a role in reducing age-related decline, supporting muscle health, and promoting overall vitality as we age.
Healthy Aging Process
Researchers have noted that our natural NAD+ (nicotinamide adenine dinucleotide) levels decline as we age, and this has been linked to a reduction in cellular repair mechanisms, mitochondrial dysfunction, and increased susceptibility to age-related diseases [1].
As a precursor compound to NAD+, NMN has been looked at for its potential to promote healthy aging by supplementing NAD+ in the body.
Research in mice has shown that NMN supplementation can effectively increase NAD+ levels, improving mitochondrial function and enhancing DNA repair [2].
Human research on NMN is still in its early stages, so there aren't many conclusions to be made, but it looks promising.
A pilot study suggested that NMN supplementation could safely elevate NAD+ levels in humans, potentially supporting metabolic function and overall health [3]. These findings support the hypothesis that NMN could be a valuable tool in promoting longevity and mitigating the effects of aging, which could help you look younger.
The mechanism behind NMN's potential to promote healthy aging lies in its ability to replenish NAD+ levels, thereby enhancing the body's ability to repair DNA, reduce oxidative stress, and maintain mitochondrial function.
Metabolism and Weight Management
Some research points to NMN's role in regulating metabolism, which could affect weight management.
By increasing NAD+ levels, NMN helps to activate enzymes called sirtuins, which are involved in metabolic regulation, fat storage, and energy expenditure. One 2011 study found that NMN supplementation in obese mice improved their insulin sensitivity and reduced weight gain, even without changes in diet [4]. This suggests that NMN may help regulate metabolic processes contributing to obesity and metabolic disorders.
There is no real research on NMN supplements for weight loss or management in humans yet, but these early findings could encourage future human clinical trials.
Energy Metabolism & Mitochondrial Health
Mitochondria, the cell's powerhouses, convert the food we eat into energy.
Studies in mice have shown that NMN supplementation can increase mitochondrial biogenesis by creating new mitochondria, leading to enhanced physical endurance and energy levels [5]. This suggests that NMN could play a role in combating fatigue and supporting overall vitality.
While more research is needed in humans, the mechanisms observed in animal studies provide a strong foundation. NAD+ is critical for mitochondrial function, and by replenishing NAD+ levels, NMN may help maintain energy production as we enter our golden years.
Exercise and Muscle Performance
During physical exercise, your muscles require significant amounts of energy produced by mitochondria. NAD+ is involved in the transfer of electrons in the mitochondria, creating ATP (adenosine triphosphate) — the primary energy currency of the cell.
By increasing NAD+ levels, NMN may enhance the efficiency of energy production, allowing muscles to work harder and longer.
A small-scale study published in 2021 observed that NMN supplementation in middle-aged and older adults improved aerobic capacity during exercise [6]. This indicates that NMN could potentially help individuals maintain or even enhance their exercise performance as they age.
Translating Animal Research to Human Benefits
Much of the excitement around NMN supplementation comes from promising observations in murine models.
These studies have shown that NMN can significantly boost NAD+ levels, enhance mitochondrial function, and extend mice's lifespan. However, these same benefits of NMN in mice may not always translate directly to humans with the same significance.
Still, initial human trials suggest that NMN supplementation can safely increase NAD+ levels in humans, similar to the effects seen in animal studies. That being said, long-term studies are needed to understand these benefits' impact better and compare them to the effects seen in animal models.
The benefits of NMN supplementation may also vary from person to person, depending on factors like age, genetics, lifestyle, and overall health.
How Does NMN Work?
NMN is a precursor to NAD+, meaning it's converted into NAD+ within the cells.
Here’s a simplified version of the process:
- Supplementation with NMN: When you dose NMN supplements, the NMN molecules enter your bloodstream and are transported to various tissues and organs throughout the body. NMN is a good precursor to NAD+ because it can cross the cell membrane directly or through specific transporters, like the newly identified Slc12a8 transporter (this differs for nicotinamide riboside (NR) as a precursor), which facilitates NMN's entry into cells.
- Conversion to NAD+: NMN is converted into NAD+ once inside the cells. This conversion is initiated by the enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT). This enzyme has three forms (NMNAT-1, NMNAT-2, and NMNAT-3) located in different parts of the cell, such as the nucleus, cytoplasm, and mitochondria. NMNAT adds an adenosine diphosphate (ADP) moiety to NMN, resulting in the formation of NAD+.
- Formation of NAD+: NAD+ is needed for redox reactions, where it alternates between its oxidized form (NAD+) and its reduced form (NADH). NAD+ participates in metabolic pathways like glycolysis, the citric acid cycle (Krebs cycle), and oxidative phosphorylation, all of which are involved in energy production. NAD+ is also needed for DNA repair, gene expression, and cellular signaling processes, particularly those involving sirtuins, a family of proteins that regulate aging and metabolism.
Why taking NMN Consistently is Key
The benefits of NMN supplementation are most likely to be seen with consistent use.
NAD+ is not a stable molecule — it's constantly used in various cellular processes, particularly energy metabolism and cellular repair. As NAD+ levels deplete, the efficiency of these processes declines.
Supplementing with NMN products provides a precursor that the body can quickly convert into NAD+, helping to restore and maintain optimal levels. This ongoing replenishment is necessary because, without consistent supplementation, NAD+ levels could drop back down, diminishing the potential benefits over time.
So whether you enjoy taking regular pre-set dosed capsules, NMN Gummies, NMN droppers, or raw NMN powder daily, starting in your 30s or 40s is a good idea. It may help to support NAD+ levels before they decline significantly preemptively.
For those in their 50s and older, it's not too late to get on top of your NAD+ levels. Consistent NMN supplementation at this stage can help maintain energy levels, support healthy aging, and promote overall cellular health.
Resources:- Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews Molecular cell biology, 22(2), 119-141.
- Shade, C. (2020). The science behind NMN–A stable, reliable NAD+ activator and anti-aging molecule. Integrative Medicine: A Clinician's Journal, 19(1), 12.
- Yi, L., Maier, A. B., Tao, R., Lin, Z., Vaidya, A., Pendse, S., ... & Kumbhar, V. (2023). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience, 45(1), 29-43.
- Zhang, Y., Zhu, W., Wang, M., Xi, P., Wang, H., & Tian, D. (2023). Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high‐fat diet. IUBMB life, 75(6), 548-562.
- Wang, H., Sun, Y., Pi, C., Yu, X., Gao, X., Zhang, C., ... & He, X. (2022). Nicotinamide mononucleotide supplementation improves mitochondrial dysfunction and rescues cellular senescence by NAD+/Sirt3 pathway in mesenchymal stem cells. International Journal of Molecular Sciences, 23(23), 14739.
- Liao, B., Zhao, Y., Wang, D., Zhang, X., Hao, X., & Hu, M. (2021). Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. Journal of the International Society of Sports Nutrition, 18, 1-9.
