Taking NMN (nicotinamide mononucleotide) and resveratrol together became popular with Dr. David Sinclair, a leading longevity researcher. NMN is a direct precursor to NAD+, so by taking NMN supplements, the idea is to elevate NAD+ levels in the blood, which naturally decline with age. NAD+ is central to many cellular processes, including DNA repair, mitochondrial health, and energy production.
On the other hand, resveratrol is a polyphenol found in berries and is known for its antioxidant properties. Resveratrol's role in supporting healthy aging lies in its potential to activate sirtuins — proteins that regulate cellular processes, including aging and stress resistance.
Resveratrol helps to protect cells from oxidative damage and may complement NMN’s effect on NAD+ production, making the two a powerful combination.
In his famous protocol, Dr. Sinclair highlights the complementary benefits of stacking multiple supplements to support healthy aging.
Most of these supplements target NAD+ levels, metabolic support, and combating oxidative stress to potentially slow down the signs of aging. While supplements like NMN and resveratrol can be part of a healthy regimen, they work best with proper nutrition, regular exercise, quality sleep, and effective stress management.
Best Time to Consume Resveratrol and NMN
Dr. David Sinclair has mentioned that he takes NMN and resveratrol in the morning, as these compounds are believed to align with the body's circadian rhythms — the body’s natural 24-hour clock that regulates sleep, energy, and important physiological processes.
NAD+ levels naturally rise during the day, so taking your NMN supplements may help to maximize your NAD+ production when your body needs them most for energy.
Another note about resveratrol, a fat-soluble compound, should be taken with a meal containing healthy fats to aid in absorption.
For those looking for an efficient solution, Our NMN + Trans-Resveratrol capsules have 500 mg of NMN and 500 mg of micronized trans-resveratrol (a more absorbable form of resveratrol) in one convenient and affordable price per mg. This makes it easy to include both compounds in your morning regimen alongside a healthy breakfast.
Benefits of NMN + Resveratrol
When combining NMN and resveratrol together, you may see synergetic benefits for cellular health, energy levels, brain function, and supporting a healthy aging process.
There are several potential pathways these NMN and resveratrol might work for this:
- Boosting NAD+: NMN supplementation is taken raise NAD+ levels in the blood. As we know, aging is often associated with a decline in NAD and is linked to signs of aging.
- Sirtuin Activation: Resveratrol is better known for its interactions with sirtuins, proteins that regulate aging, which need NAD+ to function effectively.
- Synergy for Longevity: While neither compound is FDA-approved for anti-aging, there's a lot of scientific support to show they may have benefits for supporting a healthy lifespan when combined with other positive lifestyle choices.
- Metabolism and Heart Health: NMN's impact on raising NAD+ levels helps to support mitochondrial energy, while resveratrol supports heart health and metabolism, offering a balanced approach to healthy aging.
Who Should Consider Taking Both Together?
Those who are looking to optimize their overall health — especially if they’re dealing with stress, fatigue, or low energy — could find value in combining resveratrol and NMN, as it helps support the body's mechanisms for dealing with stress and inflammation and cellular energy. The best time to take your NMN and resveratrol supplements is during the day, in line with your body's natural rhythms.
This combination is ideal for older adults looking to maintain or boost their NAD+ levels as they age, athletes and individuals leading active lifestyles may also benefit from NMN and resveratrol, as the combination may support recovery through increased mitochondrial function and cellular repair.
Before starting NMN and resveratrol, individuals with underlying health conditions or those taking medications should consult a healthcare provider to ensure these supplements are safe and appropriate for their needs.
While NMN and resveratrol are generally well-tolerated, it's always best to seek personalized advice, particularly if there are concerns about interactions or side effects.
