Top 6 Best Senolytic Supplements

Senolytic supplements help the body clear out senescent cells or cells that have stopped working properly but don't die off as they should. These "zombie cells" naturally build up as part of the aging process and eventually interfere with the function of healthy cells.

You might stumble across these supplements in blends like quercetin + fisetin, fisetin + apigenin, and fisetin + piperine. 

These blends are designed to enhance the effects of cellular senescence by targeting different biological pathways or improving absorption. Still, you don't always have to go to blends to support healthy aging. You can use pure quercetin or fisetin and some of the senolytic benefits.

But it's worth noting that the senolytic-focused blends aren't meant to be taken daily. 

Instead, experts suggest taking them two consecutive days once a month for a powerful bust of senolytic support at once and then giving the body time to recover and respond. For those looking for everyday support, most people can use single-ingredient compounds with senolytic properties in lower doses daily.

The Best Synolytic Compounds

Fisetin, quercetin, and apigenin are the best senolytic compounds, but we've put together a table of natural ingredients found in foods and drug-based compounds used in research as promising senolytic compounds and how they work to give you a bigger picture of what's currently known to work in cellular senescence.

These compounds either work to directly target and eliminate senescent cells or support cellular clean-up (reducing harmful cell signals).

Best Senolytic Supplements in 2025

1. Neurogan Health Fisetin 500 mg

2. Neurogan Health Liposomal Fisetin 1000 mg

3. LILICARE Liposomal Fisetin 1200 mg

4. Life Extension Senolytic Activator

5. Pure Encapsulations Quercetin 500 mg

6. Cenffitio Liposomal Apigenin 500mg Softgels

Neurogan Health Fisetin 500 mg

Our pure fisetin capsules are great for beginners looking for a simple, targeted senolytic with no extra fuss, making it an easy addition to most people's supplement regimens.

We use the Japanese wax tree(Rhus succundea) as the source for our fisetin, as it's a rich and clean plant source. It's highly refined to a pure yellow powder and encapsulated into vegan-friendly capsules for convenient dosing.

While you can take this senolytic compound daily, some prefer a “hit-and-run” protocol, which involves taking fisetin 2 days a month.

Neurogan Health Liposomal Fisetin 1000 mg

Our liposomal fisetin is right up your alley for those looking for a higher concentration of fisetin.

Our naturally derived fisetin is encased in a plant-based lipid layer, which protects the active compound from digestive system breakdown, meaning you end up with higher levels of fisetin in your bloodstream.

Because this is a higher dose, people looking to gain the senolytic benefits of fisetin will take liposomal fisetin intermittently rather than daily use.

LILICARE Liposomal Fisetin 1200 mg

Lilicare's liposomal fisetin is an all-in-one antioxidant and senolytic stack. It combines 1200 mg of liposomal fisetin with quercetin, resveratrol, green tea extract, and a proprietary antioxidant blend to support brain and cellular health all in one capsule.

This product can be taken daily for antioxidant support, but it's best to use it intermittently for cellular senescence.

If you already have a dialed-in supplement stack, you should take a closer look at the ingredient list to make sure you're not overdoing it with other supplements in your protocol or perhaps creating a possible bad interaction. While all-in-ones can be convenient, they require a little more finessing to ensure you're taking all the compounds in the right doses for your goals.

Life Extension Senolytic Activator

Life Extension is a supplement brand known for its evidence-based dosing and high-quality manufacturing standards. This senolytic activator combines black tea theaflavins, apigenin, and ultra-absorbable forms of quercetin and fisetin to help manage senescent cells.

Because of the targetted nature of this supplement, it's best to follow Life Extension's use guide, which recommends you take this supplement only once per week.

Pure Encapsulations Quercetin 500 mg

Quercetin is also a natural flavonoid found in foods. You'll often see it paired with fisetin, as it also provides similar support for a healthy senolytic cleanup. Still, it also has a unique advantage in that it may provide histamine regulation [7].

You can take quercetin daily for antioxidant and immune support. For senolytic use, it's often paired with other compounds and used intermittently (2-3 days/month).

Quercetin can be taken daily for antioxidant and immune support. For senolytic use, it’s often paired with other compounds and used intermittently (e.g., 2–3 days/month).

Cenffitio Liposomal Apigenin 500mg Softgels

This is a liposomal apigenin plus flavonoid blend designed to support the body's natural cell clean-up process for healthy aging.

Apigenin is the compound most commonly associated with chamomile flowers, which gives it a calming, sleepy effects, but it's also great for supporting brain health thanks to its antioxidant levels.

Apigenin can be taken daily (or nightly to support sleep). For senolytic purposes, it's often combined with fisetin or quercetin and used 2-3 times per month.

What is the Best Senolytic Supplement?

While there are many strong options for senolytic supplements, we stand by that our Fisetin 500 mg stands out as one of the best and most versatile supplements for most people.

At 500 mg per capsule, you get a research-backed fisetin dose that seamlessly fits into almost any routine.

Senolytic blends can be convenient, but they do require more attention to dosing and ingredient combinations to make sure they will work well with the rest of your supplements.

More importantly, it's essential to keep in mind that senolytic compounds aren't a quick fix for aging. However, over time, they may help support your body's ability to stay healthy and sharper longer at a cellular level.

Best Compounds Targetting Senescent Cells

Some of the best-studied natural senolytic compounds include fisetin, quercetin, and apigenin, plant-derived flavonoids with high antioxidant activity.

Not all senolytic supplements are meant to be taken every day. Some of the strongest formulas work best with the "hit-and-run" dosing method, a protocol of taking them 1-3 days consecutively and then pausing for several weeks. The idea here is that you're giving the body the opportunity to clear out the targeted senescent cells and recover naturally.

Some of our favorite senolytic compounds in single-ingredient formulas like fisetin, quercetin, and apigenin can be used daily at lower doses for their antioxidant support, but you should be more mindful of senolytic blends and make sure you're using these products as directed on the label.

Please keep in mind that all of the compounds and supplements mentioned are for cellular health support and are not medications that should be used to treat or mitigate diseases. If you have concerns, it's best to speak with a healthcare practitioner for more personalized advice.

Resources:

1. Huard, C. A., Gao, X., Dey Hazra, M. E., Dey Hazra, R. O., Lebsock, K., Easley, J. T., ... & Huard, J. (2023). Effects of Fisetin treatment on cellular senescence of various tissues and organs of old sheep. Antioxidants, 12(8), 1646.

2. Yousefzadeh, M. J., Zhu, Y. I., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & Niedernhofer, L. J. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28.

3. Yan, X., Qi, M., Li, P., Zhan, Y., & Shao, H. (2017). Apigenin in cancer therapy: Anti-cancer effects and mechanisms of action. Cell & bioscience, 7, 1-16.

4. Wang, Y., Chang, J., Liu, X., Zhang, X., Zhang, S., Zhang, X., ... & Zheng, G. (2016). Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging (Albany NY), 8(11), 2915.

5. Hickson, L. J., Prata, L. G. L., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., ... & Kirkland, J. L. (2019). Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine, 47, 446-456.

6. Zhu, Y. I., Tchkonia, T., Fuhrmann‐Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., ... & Kirkland, J. L. (2016). Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors. Aging cell, 15(3), 428-435.