NMN, or nicotinamide mononucleotide, is a form of vitamin B3 and a precursor to NAD+ (nicotinamide adenine dinucleotide), which is found in every cell and is needed for energy metabolism and most biological processes.
Research into health supplements for longevity and healthy aging has brought compounds like NMN into the spotlight. And recently, many NMN supplements have been removed from the market due to patent issues, as a major company seeks to capitalize on NMN's promising research-backed benefits.
The key to finding a good NMN dietary supplement lies in understanding the factors that affect their bioavailability — how it's absorbed and used by the body.
NMN isn't highly bioavailable, meaning that only a small percentage of the ingested supplement is taken up into the bloodstream. To optimize NMN's potential, it's recommended to look for liposomal NMN, which encapsulate the compound in fat to enhance absorption.
Alternatively, choosing supplements with a higher NMN dosage can help account for the lower bioavailability.
Determining Factors for Picking NMN
A lot of thought was put into this list. Not because we sell NMN supplements and have been passionate about health and wellness and high-quality production practices, but because we genuinely care about helping you make informed decisions for your health.
When choosing an NMN supplement, here's what we recommend you consider:
Certification and Quality Standards in Production
There are two main things we're looking for here:
- GMP Certification
- Third-Party Testing
Good Manufacturing Practices certification indicates that the NMN supplement is produced in a facility that complies with a standard for producing dietary supplements and pharmaceuticals. This standard ensures that the products are made in a clean environment that provides consistency with each batch.
Third-party testing isn't mandatory, but it's the only way for manufacturers to prove to customers that the supplement contains the stated amount of NMN and is free from contaminants such as heavy metals, pesticides, and microbial impurities.
Formulation
There's no need for fillers when it comes to NMN supplements, so make sure you choose an NMN supplement made with pure NMN powder.
Another factor to consider is NMN's bioavailability. Liposomal NMN is highly recommended as an advanced delivery system that protects NMN from digestive breakdown, increasing its absorption into the bloodstream. With liposomal NMN, you don't need as high of a dosage, so you'll see that the amount of NMN in each of the products we chose varies quite a bit from 250-1000 mg servings.
That being said, if a company chooses to use non-liposomal NMN, then you should expect a higher dose to account for some of that digestive breakdown.
Some NMN supplements include additional active ingredients like resveratrol, which may have complimentary benefits in supporting sirtuins, which are proteins that contribute to cellular health.
Brand Reputation
Trustworthy brands are transparent about their sourcing, manufacturing processes, and testing protocols, which is incredibly important for health supplements.
You can also read customer reviews and testimonials, which can provide valuable insights into the effectiveness and reliability of an NMN supplement. Look for consistent positive feedback regarding the product's benefits and the company's customer service.
Price and Value
Like most health supplements, the best results come with consistent use, which means you need to account for re-purchasing these products to get the most out of them. We like to evaluate the cost per serving to determine whether or not you're getting a good deal from your purchase.
While higher-priced products may offer superior bioavailability or additional health benefits, it's important to ensure that the price reflects the quality and efficacy of the supplement. Some brands offer subscription services or bulk purchase discounts, making long-term supplementation more affordable. Check for these options to save on costs while maintaining a consistent NMN regimen.
How Effective Are NMN Supplements?
In 2022, a groundbreaking study published in GeroScience investigated the potential effects of NMN supplementation on human health, explicitly promoting healthy aging and enhancing cellular function [1].
The study was a randomized, double-blind, placebo-controlled trial, considered the gold standard in clinical research. It involved a group of middle-aged and older adults who were administered NMN supplements over a specified period, and the participants were divided into two groups: one receiving NMN and the other receiving a placebo.
Participants in the NMN group were given 250 mg of NMN daily, a typical dosage found in many high-quality NMN supplements.
One of the study's primary outcomes was a significant increase in NAD+ levels among participants who received NMN supplementation. By boosting NAD+ levels, NMN helps to maintain cellular function and energy production.
The participants in the NMN group also showed improvements in physical performance, including better endurance and strength. This suggests that NMN supplementation can support muscle health and physical vitality, often affected by age.
Researchers also documented enhancements in cognitive function (memory, focus, and mental clarity) among those taking NMN, indicating that NMN may have neuroprotective effects and support brain health.
Another key area of improvement in this study investigating NMN supplements is reduced markers of inflammation, which is often a key contributor to age-related diseases, helping to promote overall health.
So, what do we take away from this research?
For those considering NMN supplementation, products that offer a daily dosage of 250 mg, such as those used in the study, are likely to provide noticeable health benefits. But another thing worth taking away from this research is that it is preliminary, and the FDA hasn't approved NMN to treat or mitigate any illness.
Please do not self-medicate with NMN without first consulting with a healthcare provider if you have a health condition.
Top NMN Reviews on the Market
Genuine customer reviews are a great resource when choosing an NMN supplement. Look for brands with positive feedback regarding effectiveness, quality, and customer service.
These give tremendous insight into what you can expect from a brand's services and the quality of its products.
We selected what we thought were the most heartwarming reviews we could find.
- “This stuff works! I am SO grateful that my doc recommended this to me… it’s not cheap! But I’ll be buying this forever!”
- “I'm 43 and have been using NMN for 3-4 months. Initially to enhance my workout performance and counteract potential harm and early aging from my MANY years of partying. I feel less body aches after a heavy workout, and my general mood and energy levels have improved”
- “Awesome Product, Awesome Price. I'm a 58 year-old man and did a lot of research before deciding to finally try an NMN supplement. After being on the product I can confidently say that I've noticed a difference in my alertness and improvement during work-outs. The shipments show up on time and have had no issues. I'm a very happy client!”
- “My grey hair is darkening after taking NMN, Resveratrol. And I noticed my appetite and energy level soaring. I'm a true believer in your products and taking more of your products now. Thank you so much, I'm 67 years old and getting younger as we speak!”
- “I trust Neurogan Healths NMN Supplements as they are made in a certified good manufacturing practice facility. I use many of their products and have found them to be 'as advertised'. They are my 'go to' source for supplements, bar none.”
Getting Started with NMN
Some key factors to consider when shopping for the best NMN supplements include third-party lab testing, clean ingredients, free from unnecessary additives and contaminants, production in a GMP-certified facility, and price point.
Each of the brands below have a stellar reputation for quality and customer care, and their formulations match current research on the potential of NMN supplements.
It's essential to do your research to find the product that best fits your health goals and budget.
NMN, or nicotinamide mononucleotide, is a precursor compound that supports NAD+ levels in the body. NAD+ (nicotinamide adenine dinucleotide) is important for virtually all cellular processes, including DNA repair and energy production.
So despite the fact that in 2022, the Food and Drug Administration (FDA) took NMN off the shelves as a dietary supplement due to its investigation as a new drug for anti-aging, its still possible to find the right NMN for you.
This led many brands to pivot to other NAD+ precursors, such as nicotinamide riboside (NR).
However, NMN supplements are still available if you know where to look. Here are the top nmn brands that we can recommend as a full blown supplement manufacturer:
- Neurogan Health
- ProHealth
- ReNue By Science
- DoNotAge
- OMRE
Resources:
- Yi, L., Maier, A. B., Tao, R., Lin, Z., Vaidya, A., Pendse, S., ... & Kumbhar, V. (2023). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience, 45(1), 29-43.
