NMN, or nicotinamide mononucleotide, is a form of vitamin B3 and a precursor to NAD+ (nicotinamide adenine dinucleotide), which is found in every cell and is needed for energy metabolism and most biological processes.
Research into health supplements for longevity and healthy aging has brought compounds like NMN into the spotlight. And recently, many NMN supplements have been removed from the market due to patent issues, as a major company seeks to capitalize on NMN's promising research-backed benefits.
The key to finding a good NMN dietary supplement lies in understanding the factors that affect their bioavailability — how it's absorbed and used by the body.
NMN isn't highly bioavailable, meaning that only a small percentage of the ingested supplement is taken up into the bloodstream. To optimize NMN's potential, it's recommended to look for liposomal NMN, which encapsulate the compound in fat to enhance absorption.
Alternatively, choosing supplements with a higher NMN dosage can help account for the lower bioavailability.
The Best NMN Supplementation in 2024
- Neurogan Health NMN Capsules
- Neurogan Health NMN Gummies
- Neurogan Health NMN Drops
- ReNue Health NMN Capsules
- DoNotAge NMN
- ProHealth
- OMRE NMN Resveratrol
- Genuine Purity NMN Capsules
Neurogan Health NMN Capsules
Our NMN capsules contain pure NMN in vegan-friendly vegetable cellulose capsules, making them suitable for those who prefer plant-based supplements. At 900 mg per serving (2 capsules), this is among the higher NMN doses that account for NMN's lower bioavailability.
When it comes to price point, potency, and care in production, our NMN supplements come unmatched.
Our production is in our GMP (Good Manufacturing Practice) compliant San Diego, California facility. This means that every manufacturing process adheres to strict quality control measures. To guarantee the integrity of our products, we send samples of our NMN to accredited third-party labs.
You can find a certificate of analysis for every batch to show that our NMN supplements are free from contaminants and contain the specified amount of NMN—we believe this should be a standard in the dietary supplement space.
Because we have a direct fulfillment model, we manage our stock and fulfillment in-house, eliminating the need for many middlemen services. This helps to reduce the cost of the supplements overall and minimizes our environmental impact, so you're choosing an NMN Supplement you can feel good about.
You can find most of our dietary supplements on Amazon. However, since patenting trials have taken effect, Amazon has strict policies around NMN, so you can only see it on our website, but we promise fast and secure shipping and a high-level shopping experience with customer support when you need it regardless of shopping on our website or on Amazon.
Specs:
- Price: $59.00
- NMN Per Serving: 900 mg
- Capsule Count: 90 Capsules
Review:
- “As a someone who desires longevity (or healthy aging), I didn't hesitate to snatch up Neurogan's Nicotinamide Mononucleotide (NMN) Supplement. “
- “I trust Neurogan products as they are made in a certified good manufacturing practice facility. I use many of their products and have found them to be 'as advertised'. They are my 'go to' source for supplements and hemp products, bar none.”
Neurogan Health NMN Gummies
We've been fascinated with the potential benefits of NMN supplements for a while, and it's one of the compounds that have inspired us to start our journey into cellular health supplements. In collaboration with researchers from Aalborg University, we've created several options for your NMN supplement preferences, and our NMN gummies are among the fan favorites for their easy-to-consume method.
Two NMN gummies deliver 1000 mg of pure NMN blended with vegan-friendly ingredients, catering to a wide range of dietary preferences and making them an accessible option for many.
This is the best 1000 mg NMN supplement for the price point, and it comes in a fast-dissolving gummy formula.
Specs:
- Price: $40
- NMN Per Serving: 1000 mg
- Gummy count: 120 gummies
Reviews:
- “Great company that has great products and extremely good and responsive customer service. I’m doing a recurring order and I’m very happy with the product.”
- “Very convenient, easily dividable, and quite palatable form. Healthy ingredients, much better than in tablets. Sensitive individuals might want to start with 1/4 or 1/2 of a gummy per day. Thanks for developing it and please keep up the good work.”
Neurogan Health NMN Drops
Another way we're experimenting with getting around NMN's notoriously low bioavailability is to deliver NMN in a tincture format.
Traditional NMN capsules and tablets often face the hurdle of the digestive system, where a significant portion of the compound may be broken down before it can be absorbed into the bloodstream. To circumvent this issue, we've developed NMN Drops, a sublingual (under-the-tongue) delivery system designed to enhance the bioavailability of NMN.
The sublingual method leverages the rich network of microcapillaries located under the tongue. These tiny blood vessels can rapidly absorb small active compounds like NMN directly into the bloodstream, bypassing the digestive system entirely. This method not only improves the rate of absorption but also ensures that a higher concentration of NMN reaches your cells more quickly.
Each serving of our NMN Drops delivers 250 mg of pure NMN in a 0.5 ml dose. This high-potency formulation ensures you get a significant amount of NMN with each use, making it an efficient and effective way to support your cellular health and anti-aging goals.
Specs:
- Price: $50
- NMN Per Serving: 250 mg
- Size: 60 mL (2 oz)
Reviews:
- “Great taste and absorbs quickly into the body. Just started taking and seems to be working as advertised”
- “Sublingual is the best method of absorption.”
ReNue By Science Liposomal NMN Capsules
For a long time, ReNue by Science has been considered one of the best NMN supplements on the market.
It delivers 500 mg of liposomal NMN in two vegan-based capsules to support the body's NAD+ levels. Liposomes are an advanced dietary supplement technology that encapsulates the active ingredients in a phospholipid (fat bubble) to protect and deliver them directly to the cells via the bloodstream. Because of this, you don't need an NMN dosage as high as non-liposomal products. In our research, we found this to be the best liposomal NMN supplement overall.
Specs:
- Price: $84.95
- NMN Per Serving: 500 mg
- Capsule Count: 90 capsules
Reviews:
- “All the products I’ve bought from this company have worked great. I feel more energetic!”
- “My husband and I are over 60 and wanted to boost our energy and longevity. Won’t know about the latter for awhile, but we both feel a boost in our ability to keep up with the grandchildren since we started taking this. It can be tough chasing 2-3 year olds, but this may be what’s making it a bit easier as of late.”
DoNotAGE NMN Capsules
DoNotAge is another popularly voted NMN supplement brand on forums like Reddit. This company is committed to helping many people (and pets) extend their health span with dietary supplements.
Its pure NMN Supplements come in vegetable-based capsules with 500 mg of pure NMN. A one-month supply of 60 capsules costs $65.00, making this a more mid-range priced option.
Specs:
- Price: $65.00
- NMN Per Serving: 1000 mg
- Capsule Count: 60 Capsules
Reviews:
- “I have only been taking DoNotAge supplements for only two months. I started with the beauty bundle, and I added NMN, TMG, Resveratrol, Sir6Activator and I am definitely hooked for good. I do not only feel youthful, I look better.”
- “My grey hair is darkening after taking NMN, Resveratrol. And I noticed my appetite and energy level soaring. I'm a true believer in your products and taking more of your products now. Thank you so much, I'm 67 years old and getting younger as we speak!”
ProHealth NMN Supplements
ProHealth is a well-established slow-aging wellness brand known for its high potency formulas and strict quality control standards. The brand has several formats of NMN supplements:
- Capsules
- Powders
- Liposomal NMN
- Tablets
- Lozenges
- Bulk NMN Powder
This gives you different options for different ways you can integrate NMN into your lifestyle.
Reviews:
- “Awesome Product, Awesome Price. I'm a 58 year-old man and did a lot of research before deciding to finally try an NMN supplement. After being on the product I can confidently say that I've noticed a difference in my alertness and improvement during work-outs. The shipments show up on time and have had no issues. I'm a very happy client!”
- “ I will continue to use NMN and Reserveratrol. I trust ProHealth and their dedication to our health. Science has shown that this product helps with longevity. “
OMRE NMN Resveratrol
The combination of NMN and resveratrol in OMRE's capsules is designed to deliver complementary benefits that enhance each compound's effectiveness.
Both NMN and resveratrol have been shown to support mitochondrial function, the powerhouses of cells. Improved mitochondrial function produces better energy, reduces fatigue, and enhances cellular health.
Each serving of OMRE NMN Resveratrol Capsules (2) contains 500 mg of NMN and 500 mg of resveratrol. Like the other options on this list, this product is manufactured in a GMP (Good Manufacturing Practice) certified facility. This ensures that each batch meets strict quality and purity standards and is subjected to independent lab testing to verify its potency and safety.
Specs:
- Price: $59.97
- NMN Per Serving: 500 mg + 500 mg resveratrol
- Capsule Count: 60 Capsules
Reviews:
- “This stuff works! I am SO grateful that my doc recommended this to me… it’s not cheap! But I’ll be buying this forever!”
- “In terms of quality, OMRE does not cut any corners. They manufacture their supplements in the USA and also carry out 3rd party testing which means each batch is analyzed for dose, purity, and contamination.”
Genuine Purity NMN Supplement
Genuine Purity's NMN Supplement's key feature is its liposomal formulation, which delivers nicotinamide mononucleotide in a highly bioavailable form. Each capsule contains 250 mg of NMN, and while it's not as potent as the other options on our list, the liposomal format helps ensure your body uses most of the compound in each serving and allows for a more sustained release of NMN into the bloodstream.
Specs:
- Price: $80.00
- NMN Per Serving: 250 mg
- Capsule Count: 60 Capsules
Reviews:
- “I'm 43 and have been using GenuinePurity NMN for 3-4 months. Initially to enhance my workout performance and counteract potential harm and early aging from my MANY years of partying. I feel less body aches after a heavy workout, and my general mood and energy levels have improved”
- “I've been taking GenuinePurity NMN for a few months now, and I feel more energetic and focused. My sleep quality has also improved significantly.”
Determining Factors for All Supplements
A lot of thought was put into this list. Not because we sell NMN supplements and have been passionate about health and wellness and high-quality production practices, but because we genuinely care about helping you make informed decisions for your health.
When choosing an NMN supplement, here's what we recommend you consider:
Certification and Quality Standards in Production
There are two main things we're looking for here:
- GMP Certification
- Third-Party Testing
Good Manufacturing Practices certification indicates that the NMN supplement is produced in a facility that complies with a standard for producing dietary supplements and pharmaceuticals. This standard ensures that the products are made in a clean environment that provides consistency with each batch.
Third-party testing isn't mandatory, but it's the only way for manufacturers to prove to customers that the supplement contains the stated amount of NMN and is free from contaminants such as heavy metals, pesticides, and microbial impurities.
Formulation
There's no need for fillers when it comes to NMN supplements, so make sure you choose an NMN supplement made with pure NMN powder.
Another factor to consider is NMN's bioavailability. Liposomal NMN is highly recommended as an advanced delivery system that protects NMN from digestive breakdown, increasing its absorption into the bloodstream. With liposomal NMN, you don't need as high of a dosage, so you'll see that the amount of NMN in each of the products we chose varies quite a bit from 250-1000 mg servings.
That being said, if a company chooses to use non-liposomal NMN, then you should expect a higher dose to account for some of that digestive breakdown.
Some NMN supplements include additional active ingredients like resveratrol, which may have complimentary benefits in supporting sirtuins, which are proteins that contribute to cellular health.
Brand Reputation
Trustworthy brands are transparent about their sourcing, manufacturing processes, and testing protocols, which is incredibly important for health supplements.
You can also read customer reviews and testimonials, which can provide valuable insights into the effectiveness and reliability of an NMN supplement. Look for consistent positive feedback regarding the product's benefits and the company's customer service.
Price and Value
Like most health supplements, the best results come with consistent use, which means you need to account for re-purchasing these products to get the most out of them. We like to evaluate the cost per serving to determine whether or not you're getting a good deal from your purchase.
While higher-priced products may offer superior bioavailability or additional health benefits, it's important to ensure that the price reflects the quality and efficacy of the supplement. Some brands offer subscription services or bulk purchase discounts, making long-term supplementation more affordable. Check for these options to save on costs while maintaining a consistent NMN regimen.
How Effective Are NMN Supplements?
In 2022, a groundbreaking study published in GeroScience investigated the potential effects of NMN supplementation on human health, explicitly promoting healthy aging and enhancing cellular function [1].
The study was a randomized, double-blind, placebo-controlled trial, considered the gold standard in clinical research. It involved a group of middle-aged and older adults who were administered NMN supplements over a specified period, and the participants were divided into two groups: one receiving NMN and the other receiving a placebo.
Participants in the NMN group were given 250 mg of NMN daily, a typical dosage found in many high-quality NMN supplements.
One of the study's primary outcomes was a significant increase in NAD+ levels among participants who received NMN supplementation. By boosting NAD+ levels, NMN helps to maintain cellular function and energy production.
The participants in the NMN group also showed improvements in physical performance, including better endurance and strength. This suggests that NMN supplementation can support muscle health and physical vitality, often affected by age.
Researchers also documented enhancements in cognitive function (memory, focus, and mental clarity) among those taking NMN, indicating that NMN may have neuroprotective effects and support brain health.
Another key area of improvement in this study investigating NMN supplements is reduced markers of inflammation, which is often a key contributor to age-related diseases, helping to promote overall health.
So, what do we take away from this research?
For those considering NMN supplementation, products that offer a daily dosage of 250 mg, such as those used in the study, are likely to provide noticeable health benefits. But another thing worth taking away from this research is that it is preliminary, and the FDA hasn't approved NMN to treat or mitigate any illness.
Please do not self-medicate with NMN without first consulting with a healthcare provider if you have a health condition.
Getting Started with NMN
Some key factors to consider when shopping for the best NMN supplements include third-party lab testing, clean ingredients, free from unnecessary additives and contaminants, production in a GMP-certified facility, and price point.
We've outlined a few of the top NMN supplements available on the market, including options from Neurogan Health, ReNue Health, ProHealth, and more. Each of these brands has a stellar reputation for quality and customer care, and their formulations match current research on the potential of NMN supplements.
It's essential to do your research to find the product that best fits your health goals and budget.
Resources:
- Yi, L., Maier, A. B., Tao, R., Lin, Z., Vaidya, A., Pendse, S., ... & Kumbhar, V. (2023). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience, 45(1), 29-43.
