Novusetin is a proprietary form of fisetin — a standardized extract that contains a consistent amount of fisetin each time.
Fisetin itself is a naturally occurring flavonoid (a type of antioxidant) found in plants — most supplements on the market source their fisetin from the Japanese wax tree.
Both of these compounds have been studied for their potential benefits, especially when it comes to brain and overall cognitive health.
Novusetin vs. Fisetin: Key Differences
Fisetin is the "raw ingredient," and Novusetin is the "special recipe" version.
Fisetin is found naturally in foods like strawberries, apples, and the Japanese wax tree, where it protects the plant from environmental stressors, promotes cell growth, attracts insects for pollination, and is a signal molecule for various biological processes.
While Mother Nature produces fisetin, Novusetin is a branded name for it in a formulation designed to be more reliable for formula standardization. Various companies, including Cyves Nutrition and Omega Protein Corporation, own it.
The biggest difference between Novusetin and fisetin is consistency. If you choose a fisetin supplement, the amount of fisetin you get might vary depending on the source and how it’s processed.
The thing is, you don’t get much fisetin in your average diet. For example, one serving of strawberries (100 g) contains 16,000 ㎍ fisetin, so you’d need to eat 1.4 pounds for each 100 mg of fisetin.
Novusetin, being a standardized extract, delivers a consistent dose.
This can be important if you're taking the supplement for its brain-supporting benefits, as having a stable, predictable amount of fisetin may lead to better results over time, but that doesn't mean that fisetin doesn't have health benefits — it just means you need to shop with a trusted brand that provides third-party lab testing to verify its fisetin content.
Benefits and Potential Effects
Both Novusetin and Fisetin are being studied for their ability to support healthy aging, particularly brain health benefits.
Preclinical studies suggest that fisetin may help protect cells from oxidative stress, the body's version of rusting [1].
Novusetin, being a form of fisetin, offers the same potential benefits but with a twist: it’s standardized, so the amount of fisetin is, in theory, more reliable. This could be helpful if you’re looking to support memory and cognitive function and want to ensure you get the same dose daily without any guesswork.
Please remember that most of the research on fisetin has been done in preclinical settings — meaning on cells or animals rather than in large human trials. This means we need more studies that investigate its effects in humans, specifically when we're talking about crossing the blood-brain barrier and its potential to promote neuronal cell growth, but the early results are promising.
Availability and Cost
In our research, we've found that, on average, fisetin supplements cost between $20 and $50 per bottle (typically a one-month supply), and the price fluctuates depending on the potency of fisetin.
Novusetin, being a branded extract, tends to be less widely available than fisetin supplements, and it might also come with a higher price tag. This is because it's a branded fisetin form, which can give you more confidence in what you’re taking but often adds to the cost.
Fisetin supplements, like capsules or powders, are commonly found at local supplement stores or online platforms like Amazon. They may come in various forms and formulations and are generally cheaper compared to Novusetin supplements.
You’ll see fisetin listed as an ingredient on its own or sometimes in blends with other antioxidants. Since it’s naturally sourced, the quality can vary between brands.
At Neurogan Health, we have one of the most affordable fisetin options for potency and quality.
Our one-month supply of Fisetin Capsules costs $31 and contains 500 mg of Japanese Fruit Wax Tree fisetin per serving.
Which One Should You Choose?
Choosing between Novusetin and Fisetin really comes down to what you value most in a supplement.
If you want a reliable, consistent product where you know exactly how much fisetin you’re getting each time and are unsure of the brands offering fisetin supplements, checking to see if the fisetin they use is Novusetin might be worth considering — as it can put your decision to purchase at ease.
However, if you’re looking for a more affordable option or want something you can easily find, a regular fisetin supplement could work well. Just make sure to look for a reputable brand that shares details about sourcing and quality testing so you know you’re getting a good product.
One isn't necessarily better than the other, but knowing that Nouvsetin is a standardized form of fisetin can help give you a sign of quality in a product if you're unfamiliar with the brand but it’s also possible to purchase pure fisetin supplements that have been tested to show you the exact measurement of fisetin in each capsule.
Resources:
- Khan, N., Syed, D. N., Ahmad, N., & Mukhtar, H. (2013). Fisetin: a dietary antioxidant for health promotion. Antioxidants & redox signaling, 19(2), 151-162.
