Nicotinamide mononucleotide (NMN) is a derivative of vitamin B3 and a precursor to NAD+ — a coenzyme needed for all cellular functions. The ultimate goal of taking NMN supplements is to support healthy NAD+ levels to maintain overall health as we age. However, a recent study found that NMN may also help promote hair growth by enhancing cell proliferation, reducing oxidative stress, and mitigating inflammation in the hair follicles, which are all major components of regulating hair follicles [1].
Does it mean we should start looking at NMN supplements as the new Rogaine?
Not just yet, as the research isn’t as well established as minoxidil — the active ingredient in Rogaine. That said, we'll take a closer look at the studies relating to NMN's potential in age-related hair loss.
The Science of NMN and Its Effect on Hair Growth
Hair growth is a complex process influenced by genetics, hormone levels, and stress.
Hormones are a big part of the conversation when it comes to hair health. Dihydrotestosterone (DHT), an androgen hormone derived from testosterone, can be related to hair loss, especially in conditions like androgenetic alopecia (pattern baldness).
While DHT helps during puberty to develop male traits, such as facial hair growth, in adults, it can contribute to hair follicle shrinkage in androgenetic alopecia, also known as male or female pattern baldness.
DHT is more directly connected to hormones and genetics, but stress can play an indirect role. Chronic stress can disrupt hormone balance and contribute to conditions that promote hair loss.
In one particular study conducted on mice, NMN could help undo the damage to the hair follicles caused by DHT by lowering certain chemicals that lead to inflammation (IL-6 and TNF-α). The study revealed that NMN also boosted growth factors like VEGF, which helps increase blood flow to the hair follicles. More blood flow means the follicles get more nutrients, which allows them to grow healthier [1].
Before you get your hopes up on NMN for hair regrowth, we need to reiterate that these results were promising in mice. While this doesn't necessarily mean NMN will work the same way in humans, it's a good start for advancing more research in new hair regrowth treatments.
Should I Use NMN for Hair Growth?
NMN supplements are a great addition to a dialed-in wellness routine for supporting healthy aging and, based on some early research, might even help with healthy hair growth. Still, please remember the results can vary from person to person.
There are several ways NMN might support aspects of the hair growth cycle:
- Reducing Oxidative Stress: NMN is a potential antioxidant that helps fight against oxidative stress, which contributes to thinning hair and loss [2]. By supporting the body's resistance against oxidative stress, taking NMN regularly may help create a healthier environment for hair follicles to thrive.
- Inflammation Support: NMN has been shown to suppress the NF-κB p65 signaling pathway in mice, which is part of the inflammation response [3]. In the first study we mentioned, NMN-treated hair cells had less inflammation than those only treated with DHT, helping to maintain hair follicle health [1].
- Promoting Growth Factor Expression: NMN has been shown to increase VEGF, which supports the formation of blood vessels. This increased blood flow may help hair follicles receive more nutrients and oxygen, potentially supporting healthier hair growth [1].
- Supporting Cellular Health: People mainly take NMN to support cellular health, which can affect the cells involved in hair growth through the Wnt/β-catenin pathway [1].
Minoxidil Vs. NMN for Promoting Hair Regrowth
Minoxidil — commonly found under the brand name "Rogaine" — is an FDA-approved treatment for hair loss that works topically by supporting the hair-growth cycle and widening blood vessels to improve blood flow to hair follicles, promoting hair growth.
On the other hand, NMN is being studied for its potential to support hair growth by reducing inflammation, increasing blood flow, and activating growth pathways in hair follicles. Unlike minoxidil, NMN effectiveness in humans is still not fully understood.
Will NMN Cause Hair Loss?
The good news is that no evidence shows NMN causes hair loss.
Most of the research points to NMN promoting hair growth. However, unlike medications like finasteride, which block the production of DHT, NMN appears to promote a healthier cellular environment without directly interfering with hormone levels.
While this is undoubtedly good for people looking to prevent age-related hair loss, most of the research comes from preliminary studies on animals or in vitro experiments. It's possible that individual responses to NMN can vary — some might not notice a difference in their hair regrowth, while others might find some luck.
People with existing medical conditions or hair loss concerns should consult a healthcare professional before considering NMN supplements.
Does NMN Help with Hair Thinning?
We've highlighted a recent study promising NMN as a supportive supplement for hair growth, but it doesn't mean it's a surefire treatment against hair thinning or regrowth.
As an NAD+ precursor, NMN has some health benefits like supporting oxidative stress, maintaining healthy inflammation, and promoting nutrient delivery, making this compound an intriguing supplement, but it shouldn't be seen as a replacement for established hair loss treatments like Rogaine (minoxidil).
For those looking to explore new options for hair care, NMN could be a complementary supplement to support overall cellular health, which may indirectly benefit hair follicles.
Resources:
- Xu, C., Dai, J., Ai, H., Du, W., & Ji, H. (2024). β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress. Molecules, 29(4), 798.
- Nadeeshani, H., Li, J., Ying, T., Zhang, B., & Lu, J. (2022). Nicotinamide mononucleotide (NMN) as an anti-aging health product–promises and safety concerns. Journal of advanced research, 37, 267-278.
- Shade, C. (2020). The science behind NMN–A stable, reliable NAD+ activator and anti-aging molecule. Integrative Medicine: A Clinician's Journal, 19(1), 12.
